Procollagen galactosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a procollagen galactosyltransferase (EC 2.4.1.50) is an enzyme that catalyzes the chemical reaction

UDP-galactose + procollagen 5-hydroxy-L-lysine $\rightleftharpoons$ UDP + procollagen 5-(D-galactosyloxy)-L-lysine

Thus, the two substrates of this enzyme are UDP-galactose and procollagen 5-hydroxy-L-lysine, whereas its two products are UDP and procollagen 5-(D-galactosyloxy)-L-lysine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase. Other names in common use include hydroxylysine galactosyltransferase, collagen galactosyltransferase, collagen hydroxylysyl galactosyltransferase, UDP galactose-collagen galactosyltransferase, uridine diphosphogalactose-collagen galactosyltransferase, and UDPgalactose:5-hydroxylysine-collagen galactosyltransferase. This enzyme participates in lysine degradation.

[edit] References

IUBMB entry for 2.4.1.50
BRENDA references for 2.4.1.50 (Recommended.)
PubMed references for 2.4.1.50
PubMed Central references for 2.4.1.50
Google Scholar references for 2.4.1.50
Bosmann HB, Eylar EH (1968). "Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen". Biochem. Biophys. Res. Commun. 33: 340–6. PMID 5722225.
Kivirikko KI and Myllyla R. "In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23".