PROX1

From Wikipedia, the free encyclopedia


Prospero-related homeobox 1
Identifiers
Symbol(s) PROX1;
External IDs OMIM: 601546 MGI: 97772 HomoloGene: 2069
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5629 19130
Ensembl ENSG00000117707 ENSMUSG00000010175
Uniprot Q92786 P48437
Refseq NM_002763 (mRNA)
NP_002754 (protein)		 NM_008937 (mRNA)
NP_032963 (protein)
Location Chr 1: 212.23 - 212.28 Mb Chr 1: 191.82 - 191.86 Mb
Pubmed search [1] [2]

Prospero-related homeobox 1, also known as PROX1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: PROX1 prospero-related homeobox 1.

[edit] Further reading

  • Zinovieva RD, Duncan MK, Johnson TR, et al. (1996). "Structure and chromosomal localization of the human homeobox gene Prox 1.". Genomics 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486. 
  • Wigle JT, Chowdhury K, Gruss P, Oliver G (1999). "Prox1 function is crucial for mouse lens-fibre elongation.". Nat. Genet. 21 (3): 318–22. doi:10.1038/6844. PMID 10080188. 
  • Mouta Carreira C, Nasser SM, di Tomaso E, et al. (2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.". Cancer Res. 61 (22): 8079–84. PMID 11719431. 
  • Rodriguez-Niedenführ M, Papoutsi M, Christ B, et al. (2002). "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts.". Anat. Embryol. 204 (5): 399–406. PMID 11789987. 
  • Duncan MK, Cui W, Oh DJ, Tomarev SI (2002). "Prox1 is differentially localized during lens development.". Mech. Dev. 112 (1-2): 195–8. PMID 11850194. 
  • Chen Q, Dowhan DH, Liang D, et al. (2002). "CREB-binding protein/p300 co-activation of crystallin gene expression.". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779. 
  • Wilting J, Papoutsi M, Christ B, et al. (2002). "The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.". FASEB J. 16 (10): 1271–3. doi:10.1096/fj.01-1010fje. PMID 12060670. 
  • Petrova TV, Mäkinen T, Mäkelä TP, et al. (2002). "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.". EMBO J. 21 (17): 4593–9. PMID 12198161. 
  • Hong YK, Harvey N, Noh YH, et al. (2003). "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.". Dev. Dyn. 225 (3): 351–7. doi:10.1002/dvdy.10163. PMID 12412020. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Dyer MA, Livesey FJ, Cepko CL, Oliver G (2003). "Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina.". Nat. Genet. 34 (1): 53–8. doi:10.1038/ng1144. PMID 12692551. 
  • Nagai H, Li Y, Hatano S, et al. (2003). "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies.". Genes Chromosomes Cancer 38 (1): 13–21. doi:10.1002/gcc.10248. PMID 12874782. 
  • Steffensen KR, Holter E, Båvner A, et al. (2005). "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue.". EMBO Rep. 5 (6): 613–9. doi:10.1038/sj.embor.7400147. PMID 15143342. 
  • Qin J, Gao DM, Jiang QF, et al. (2005). "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene.". Mol. Endocrinol. 18 (10): 2424–39. doi:10.1210/me.2004-0009. PMID 15205472. 
  • Dudas J, Papoutsi M, Hecht M, et al. (2005). "The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium.". Anat. Embryol. 208 (5): 359–66. doi:10.1007/s00429-004-0403-4. PMID 15232737. 
  • Reis RM, Reis-Filho JS, Longatto Filho A, et al. (2006). "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors.". Pathol. Res. Pract. 201 (12): 771–6. doi:10.1016/j.prp.2005.08.010. PMID 16308102. 
  • Song KH, Li T, Chiang JY (2006). "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.". J. Biol. Chem. 281 (15): 10081–8. doi:10.1074/jbc.M513420200. PMID 16488887. 
  • Schneider M, Büchler P, Giese N, et al. (2006). "Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread.". Int. J. Oncol. 28 (4): 883–90. PMID 16525637. 
  • Shimoda M, Takahashi M, Yoshimoto T, et al. (2006). "A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma.". Clin. Cancer Res. 12 (20 Pt 1): 6005–11. doi:10.1158/1078-0432.CCR-06-0712. PMID 17062673. 
  • Laerm A, Helmbold P, Goldberg M, et al. (2007). "Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system.". J. Hepatol. 46 (1): 89–97. doi:10.1016/j.jhep.2006.07.033. PMID 17069925. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD