PRMT6

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Protein arginine methyltransferase 6
Identifiers
Symbol(s) PRMT6; FLJ10559; HRMT1L6
External IDs OMIM: 608274 MGI: 2139971 HomoloGene: 10024
Orthologs
Human Mouse
Entrez 55170 99890
Ensembl ENSG00000198890 ENSMUSG00000049300
Uniprot Q96LA8 Q6NZB1
Refseq NM_018137 (mRNA)
NP_060607 (protein)		 NM_178891 (mRNA)
NP_849222 (protein)
Location Chr 1: 107.4 - 107.4 Mb Chr 3: 110.37 - 110.38 Mb
Pubmed search [1] [2]

Protein arginine methyltransferase 6, also known as PRMT6, is a human gene.[1]

Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: PRMT6 protein arginine methyltransferase 6.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Frankel A, Yadav N, Lee J, et al. (2002). "The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.". J. Biol. Chem. 277 (5): 3537-43. doi:10.1074/jbc.M108786200. PMID 11724789. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Boulanger MC, Liang C, Russell RS, et al. (2005). "Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression.". J. Virol. 79 (1): 124-31. doi:10.1128/JVI.79.1.124-131.2005. PMID 15596808. 
  • Sgarra R, Lee J, Tessari MA, et al. (2006). "The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6.". J. Biol. Chem. 281 (7): 3764-72. doi:10.1074/jbc.M510231200. PMID 16293633. 
  • Willemsen NM, Hitchen EM, Bodetti TJ, et al. (2007). "Protein methylation is required to maintain optimal HIV-1 infectivity.". Retrovirology 3: 92. doi:10.1186/1742-4690-3-92. PMID 17169163. 
  • Invernizzi CF, Xie B, Richard S, Wainberg MA (2007). "PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA.". Retrovirology 3: 93. doi:10.1186/1742-4690-3-93. PMID 17176473. 
  • Xie B, Invernizzi CF, Richard S, Wainberg MA (2007). "Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region.". J. Virol. 81 (8): 4226-34. doi:10.1128/JVI.01888-06. PMID 17267505. 
  • Guccione E, Bassi C, Casadio F, et al. (2007). "Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.". Nature 449 (7164): 933-7. doi:10.1038/nature06166. PMID 17898714. 
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