PRMT2

From Wikipedia, the free encyclopedia

Protein arginine methyltransferase 2

PDB rendering based on 1x2p.

Available structures: 1x2p

Identifiers

Symbol(s)

PRMT2; HRMT1L1; MGC111373

External IDs

OMIM: 601961 MGI: 1316652 HomoloGene: 55587

Gene ontology
Molecular Function:	• signal transducer activity • methyltransferase activity • transferase activity • identical protein binding
Cellular Component:	• nucleus
Biological Process:	• protein amino acid methylation • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001535 (mRNA)
NP_001526 (protein)

NM_001077638 (mRNA)
NP_001071106 (protein)

Location

Chr 21: 46.88 - 46.91 Mb

Chr 10: 75.65 - 75.68 Mb

Pubmed search

[1]

[2]

Protein arginine methyltransferase 2, also known as PRMT2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PRMT2 protein arginine methyltransferase 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Katsanis N, Yaspo ML, Fisher EM (1997). "Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene.". Mamm. Genome 8 (7): 526–9. PMID 9196002.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Scott HS, Antonarakis SE, Lalioti MD, et al. (1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).". Genomics 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Kzhyshkowska J, Schütt H, Liss M, et al. (2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1.". Biochem. J. 358 (Pt 2): 305–14. PMID 11513728.
Qi C, Chang J, Zhu Y, et al. (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.". J. Biol. Chem. 277 (32): 28624–30. doi:10.1074/jbc.M201053200. PMID 12039952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ganesh L, Yoshimoto T, Moorthy NC, et al. (2006). "Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.". Mol. Cell. Biol. 26 (10): 3864–74. doi:10.1128/MCB.26.10.3864-3874.2006. PMID 16648481.