PRKY

From Wikipedia, the free encyclopedia

Protein kinase, Y-linked

Identifiers

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_002760 (mRNA)
NP_002751 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr Y: 7.2 - 7.31 Mb

n/a

Pubmed search

[1]

n/a

Protein kinase, Y-linked, also known as PRKY, is a human gene.^[1]

This gene encodes a member of the cAMP-dependent serine/threonine protein kinase family. This gene is located on chromosome Y, near the boundary of the pseudoautosomal region. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRKY protein kinase, Y-linked.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825-37. doi:10.1038/nature01722. PMID 12815422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Jobling MA, Williams GA, Schiebel GA, et al. (1999). "A selective difference between human Y-chromosomal DNA haplotypes.". Curr. Biol. 8 (25): 1391-4. PMID 9889101.
Schiebel K, Winkelmann M, Mertz A, et al. (1998). "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.". Hum. Mol. Genet. 6 (11): 1985-9. PMID 9302280.
Schiebel K, Mertz A, Winkelmann M, et al. (1997). "FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.". Cytogenet. Cell Genet. 76 (1-2): 49-52. PMID 9154127.
Gläser B, Hierl T, Taylor K, et al. (1997). "High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin.". Chromosome Res. 5 (1): 23-30. PMID 9088640.
Klink A, Schiebel K, Winkelmann M, et al. (1995). "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.". Hum. Mol. Genet. 4 (5): 869-78. PMID 7633447.