PRKRIR

From Wikipedia, the free encyclopedia

Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

Identifiers

PRKRIR; DAP4; MGC102750; P52rIPK

External IDs

OMIM: 607374 MGI: 1920231 HomoloGene: 37952

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding • protein dimerization activity
Cellular Component:	• nucleus
Biological Process:	• response to stress • signal transduction • negative regulation of cell proliferation

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_004705 (mRNA)
NP_004696 (protein)

NM_028410 (mRNA)
NP_082686 (protein)

Location

n/a

Chr 7: 98.58 - 98.59 Mb

Pubmed search

[1]

[2]

Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor), also known as PRKRIR, is a human gene.^[1]

[edit] References

^ Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor).

[edit] Further reading

Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases.". Biochem. Biophys. Res. Commun. 178 (2): 430–7. PMID 1677563.
Polyak SJ, Tang N, Wambach M, et al. (1996). "The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.". J. Biol. Chem. 271 (3): 1702–7. PMID 8576172.
Gale M, Blakely CM, Hopkins DA, et al. (1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK.". Mol. Cell. Biol. 18 (2): 859–71. PMID 9447982.
Shi Y, Vattem KM, Sood R, et al. (1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.". Mol. Cell. Biol. 18 (12): 7499–509. PMID 9819435.
Lu J, O'Hara EB, Trieselmann BA, et al. (1999). "The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha.". J. Biol. Chem. 274 (45): 32198–203. PMID 10542257.
Saelens X, Kalai M, Vandenabeele P (2001). "Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation.". J. Biol. Chem. 276 (45): 41620–8. doi:10.1074/jbc.M103674200. PMID 11555640.
Lin Y, Khokhlatchev A, Figeys D, Avruch J (2003). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.". J. Biol. Chem. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. PMID 12384512.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee JH, Choi SR, Hwang TH, et al. (2004). "A gene expression in study human gastric adenocarcinoma using a cDNA microarray.". The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 42 (6): 484–95. PMID 14695705.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.