PRKG1

From Wikipedia, the free encyclopedia

Protein kinase, cGMP-dependent, type I

Identifiers

Symbol(s)

PRKG1; CGKI; FLJ36117; MGC71944; PGK; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha

External IDs

OMIM: 176894 MGI: 108174 HomoloGene: 55964

EC number

2.7.11.12

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • cGMP-dependent protein kinase activity • protein binding • ATP binding • cAMP-dependent protein kinase regulator activity • transferase activity • cGMP binding
Cellular Component:	• Golgi apparatus • cAMP-dependent protein kinase complex
Biological Process:	• neuron migration • protein amino acid phosphorylation • regulation of smooth muscle contraction • signal transduction • dendrite development • actin cytoskeleton organization and biogenesis • forebrain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006258 (mRNA)
NP_006249 (protein)

XM_993724 (mRNA)
XP_998818 (protein)

Location

Chr 10: 52.42 - 53.73 Mb

Chr 19: 30.64 - 31.83 Mb

Pubmed search

[1]

[2]

Protein kinase, cGMP-dependent, type I, also known as PRKG1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I.

[edit] Further reading

Picciotto MR, Cohn JA, Bertuzzi G, et al. (1992). "Phosphorylation of the cystic fibrosis transmembrane conductance regulator.". J. Biol. Chem. 267 (18): 12742–52. PMID 1377674.
Orstavik S, Sandberg M, Bérubé D, et al. (1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10.". Cytogenet. Cell Genet. 59 (4): 270–3. PMID 1544322.
Thomas MK, Francis SH, Corbin JD (1990). "Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.". J. Biol. Chem. 265 (25): 14971–8. PMID 2168396.
Sandberg M, Natarajan V, Ronander I, et al. (1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat.". FEBS Lett. 255 (2): 321–9. PMID 2792381.
Pöhler D, Butt E, Meissner J, et al. (1995). "Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system.". FEBS Lett. 374 (3): 419–25. PMID 7589584.
Komalavilas P, Lincoln TM (1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.". J. Biol. Chem. 269 (12): 8701–7. PMID 8132598.
Butt E, Abel K, Krieger M, et al. (1994). "cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.". J. Biol. Chem. 269 (20): 14509–17. PMID 8182057.
Suko J, Maurer-Fogy I, Plank B, et al. (1993). "Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.". Biochim. Biophys. Acta 1175 (2): 193–206. PMID 8380342.
Tamura N, Itoh H, Ogawa Y, et al. (1996). "cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase.". Hypertension 27 (3 Pt 2): 552–7. PMID 8613202.
Salih E, Zhou HY, Glimcher MJ (1996). "Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases.". J. Biol. Chem. 271 (28): 16897–905. PMID 8663267.
Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.". Science 273 (5277): 959–63. PMID 8688081.
Orstavik S, Natarajan V, Taskén K, et al. (1997). "Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1).". Genomics 42 (2): 311–8. doi:10.1006/geno.1997.4743. PMID 9192852.
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMID 9687510.
Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB.". J. Biol. Chem. 273 (49): 32377–9. PMID 9829964.
Endo S, Suzuki M, Sumi M, et al. (1999). "Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2467–72. PMID 10051666.
Wang X, Bruderer S, Rafi Z, et al. (1999). "Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.". EMBO J. 18 (16): 4549–59. doi:10.1093/emboj/18.16.4549. PMID 10449420.
Surks HK, Mochizuki N, Kasai Y, et al. (1999). "Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.". Science 286 (5444): 1583–7. PMID 10567269.
Yuasa K, Michibata H, Omori K, Yanaka N (2000). "A novel interaction of cGMP-dependent protein kinase I with troponin T.". J. Biol. Chem. 274 (52): 37429–34. PMID 10601315.
Yuasa K, Omori K, Yanaka N (2000). "Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha.". J. Biol. Chem. 275 (7): 4897–905. PMID 10671526.
Huber A, Neuhuber WL, Klugbauer N, et al. (2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle.". J. Biol. Chem. 275 (8): 5504–11. PMID 10681529.