PRKCQ

From Wikipedia, the free encyclopedia

Protein kinase C, theta

PDB rendering based on 1xjd.

Available structures: 1xjd

Identifiers

Symbol(s)

PRKCQ; MGC126514; MGC141919; PRKCT; nPKC-theta

External IDs

OMIM: 600448 MGI: 97601 HomoloGene: 21263

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein kinase C activity • protein binding • ATP binding • zinc ion binding • transferase activity • diacylglycerol binding
Cellular Component:	• immunological synapse • intracellular • cytoplasm • plasma membrane
Biological Process:	• regulation of cell growth • protein amino acid phosphorylation • intracellular signaling cascade • positive regulation of T cell proliferation • positive regulation of interleukin-2 biosynthetic process • activation of NF-kappaB transcription factor

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006257 (mRNA)
NP_006248 (protein)

NM_008859 (mRNA)
NP_032885 (protein)

Location

Chr 10: 6.51 - 6.66 Mb

Chr 2: 11.09 - 11.22 Mb

Pubmed search

[1]

[2]

Protein kinase C, theta, also known as PRKCQ, is a human gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.^[1]

[edit] See also

Protein kinase C

[edit] References

^ Entrez Gene: PRKCQ protein kinase C, theta.

[edit] Further reading

Meller N, Altman A, Isakov N (1998). "New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C.". Stem Cells 16 (3): 178–92. PMID 9617893.
Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. PMID 12734410.
Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.". Cell. Immunol. 137 (1): 1–13. PMID 1832084.
Chowdhury IH, Koyanagi Y, Kobayashi S, et al. (1990). "The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.". Virology 176 (1): 126–32. PMID 1970444.
Ruegg CL, Strand M (1990). "Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.". J. Immunol. 144 (10): 3928–35. PMID 2139676.
Jakobovits A, Rosenthal A, Capon DJ (1990). "Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.". EMBO J. 9 (4): 1165–70. PMID 2182321.
Fields AP, Bednarik DP, Hess A, May WS (1988). "Human immunodeficiency virus induces phosphorylation of its cell surface receptor.". Nature 333 (6170): 278–80. doi:10.1038/333278a0. PMID 3259291.
Chirmule N, Goonewardena H, Pahwa S, et al. (1995). "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.". J. Biol. Chem. 270 (33): 19364–9. PMID 7642615.
Chang JD, Xu Y, Raychowdhury MK, Ware JA (1993). "Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets.". J. Biol. Chem. 268 (19): 14208–14. PMID 7686153.
Erdel M, Baier-Bitterlich G, Duba C, et al. (1995). "Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH.". Genomics 25 (2): 595–7. PMID 7790001.
Ward NE, Gravitt KR, O'Brian CA (1995). "Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.". Cancer Lett. 88 (1): 37–40. PMID 7850771.
Gupta S, Aggarwal S, Kim C, Gollapudi S (1994). "Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.". Int. J. Immunopharmacol. 16 (3): 197–204. PMID 8206685.
Baier G, Telford D, Giampa L, et al. (1993). "Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.". J. Biol. Chem. 268 (7): 4997–5004. PMID 8444877.
Parada NA, Cruikshank WW, Danis HL, et al. (1996). "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.". Cell. Immunol. 168 (1): 100–6. doi:10.1006/cimm.1996.0054. PMID 8599832.
Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.". J. Virol. 70 (3): 1384–9. PMID 8627654.
Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P (1996). "The HIV nef protein associates with protein kinase C theta.". J. Biol. Chem. 271 (28): 16753–7. PMID 8663223.
Meller N, Liu YC, Collins TL, et al. (1996). "Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function.". Mol. Cell. Biol. 16 (10): 5782–91. PMID 8816492.
Holmes AM (1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.". Arch. Biochem. Biophys. 335 (1): 8–12. doi:10.1006/abbi.1996.0476. PMID 8914829.
Monks CR, Kupfer H, Tamir I, et al. (1997). "Selective modulation of protein kinase C-theta during T-cell activation.". Nature 385 (6611): 83–6. doi:10.1038/385083a0. PMID 8985252.
Datta R, Kojima H, Yoshida K, Kufe D (1997). "Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis.". J. Biol. Chem. 272 (33): 20317–20. PMID 9252332.