PRKCI

From Wikipedia, the free encyclopedia

Protein kinase C, iota

PDB rendering based on 1vd2.

Available structures: 1vd2, 1wmh, 1zrz

Identifiers

Symbol(s)

PRKCI; DXS1179E; MGC26534; PKCI; nPKC-iota

External IDs

OMIM: 600539 MGI: 99260 HomoloGene: 37667

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • atypical protein kinase C activity • protein binding • ATP binding • phospholipid binding • zinc ion binding • transferase activity • diacylglycerol binding • metal ion binding
Cellular Component:	• polarisome • nucleus • cytoplasm • cytosol • apical part of cell
Biological Process:	• protein amino acid phosphorylation • protein targeting to membrane • cytoskeleton organization and biogenesis • actin filament organization • intracellular signaling cascade • membrane organization and biogenesis • vesicle-mediated transport • establishment of apical/basal cell polarity • eye photoreceptor cell development • establishment and/or maintenance of epithelial cell polarity • intercellular junction assembly and maintenance • secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002740 (mRNA)
NP_002731 (protein)

NM_008857 (mRNA)
NP_032883 (protein)

Location

Chr 3: 171.42 - 171.51 Mb

Chr 3: 31.19 - 31.24 Mb

Pubmed search

[1]

[2]

Protein kinase C, iota, also known as PRKCI, is a human gene.^[1]

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRKCI protein kinase C, iota.

[edit] Further reading

Suzuki A, Akimoto K, Ohno S (2003). "Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms.". J. Biochem. 133 (1): 9–16. PMID 12761193.
Fields AP, Regala RP (2007). "Protein kinase C iota: human oncogene, prognostic marker and therapeutic target.". Pharmacol. Res. 55 (6): 487–97. doi:10.1016/j.phrs.2007.04.015. PMID 17570678.
Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.". Cell. Immunol. 137 (1): 1–13. PMID 1832084.
Chowdhury IH, Koyanagi Y, Kobayashi S, et al. (1990). "The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.". Virology 176 (1): 126–32. PMID 1970444.
Ruegg CL, Strand M (1990). "Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.". J. Immunol. 144 (10): 3928–35. PMID 2139676.
Jakobovits A, Rosenthal A, Capon DJ (1990). "Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.". EMBO J. 9 (4): 1165–70. PMID 2182321.
Fields AP, Bednarik DP, Hess A, May WS (1988). "Human immunodeficiency virus induces phosphorylation of its cell surface receptor.". Nature 333 (6170): 278–80. doi:10.1038/333278a0. PMID 3259291.
Mazzarella R, Ciccodicola A, Esposito T, et al. (1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3.". Genomics 26 (3): 629–31. PMID 7607695.
Chirmule N, Goonewardena H, Pahwa S, et al. (1995). "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.". J. Biol. Chem. 270 (33): 19364–9. PMID 7642615.
Ward NE, Gravitt KR, O'Brian CA (1995). "Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.". Cancer Lett. 88 (1): 37–40. PMID 7850771.
Gupta S, Aggarwal S, Kim C, Gollapudi S (1994). "Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.". Int. J. Immunopharmacol. 16 (3): 197–204. PMID 8206685.
Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ (1993). "Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.". J. Biol. Chem. 268 (32): 24296–302. PMID 8226978.
Diaz-Meco MT, Municio MM, Sanchez P, et al. (1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.". Mol. Cell. Biol. 16 (1): 105–14. PMID 8524286.
Parada NA, Cruikshank WW, Danis HL, et al. (1996). "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.". Cell. Immunol. 168 (1): 100–6. doi:10.1006/cimm.1996.0054. PMID 8599832.
Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.". J. Virol. 70 (3): 1384–9. PMID 8627654.
Díaz-Meco MT, Municio MM, Frutos S, et al. (1996). "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C.". Cell 86 (5): 777–86. PMID 8797824.
Holmes AM (1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.". Arch. Biochem. Biophys. 335 (1): 8–12. doi:10.1006/abbi.1996.0476. PMID 8914829.
Murray NR, Fields AP (1997). "Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis.". J. Biol. Chem. 272 (44): 27521–4. PMID 9346882.
Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795.
Sanchez P, De Carcer G, Sandoval IV, et al. (1998). "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.". Mol. Cell. Biol. 18 (5): 3069–80. PMID 9566925.