PRKCG

From Wikipedia, the free encyclopedia

Protein kinase C, gamma
PDB rendering based on 1tbn.
Available structures: 1tbn, 1tbo, 2uzp
Identifiers
Symbol(s)	PRKCG; MGC57564; PKC-gamma; PKCC; PKCG; SCA14
External IDs	OMIM: 176980 HomoloGene: 20602
Gene ontology Molecular Function: • nucleotide binding • protein kinase C activity • calcium ion binding • ATP binding • zinc ion binding • transferase activity • diacylglycerol binding Biological Process: • protein amino acid phosphorylation • intracellular signaling cascade • cell death • negative regulation of protein ubiquitination • positive regulation of mismatch repair • negative regulation of protein catabolic process
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5582	n/a
Ensembl	ENSG00000126583	n/a
Uniprot	P05129	n/a
Refseq	NM_002739 (mRNA) NP_002730 (protein)	n/a (mRNA) n/a (protein)
Location	Chr 19: 59.08 - 59.1 Mb	n/a
Pubmed search	[1]	n/a

Protein kinase C, gamma, also known as PRKCG, is a human gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).^[1]

[edit] See also

• Protein kinase C

[edit] References

[edit] Further reading