PRKCE

From Wikipedia, the free encyclopedia

Protein kinase C, epsilon

PDB rendering based on 1gmi.

Available structures: 1gmi

Identifiers

Symbol(s)

PRKCE; MGC125656; MGC125657; PKCE; nPKC-epsilon

External IDs

OMIM: 176975 MGI: 97599 HomoloGene: 48343

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • calcium-independent protein kinase C activity • signal transducer activity • ATP binding • zinc ion binding • transferase activity • diacylglycerol binding • metal ion binding
Cellular Component:	• membrane fraction • nucleus • cytoplasm
Biological Process:	• protein amino acid phosphorylation • induction of apoptosis • intracellular signaling cascade • regulation of peptidyl-tyrosine phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005400 (mRNA)
NP_005391 (protein)

XM_989478 (mRNA)
XP_994572 (protein)

Location

Chr 2: 45.73 - 46.27 Mb

Chr 17: 86.08 - 86.56 Mb

Pubmed search

[1]

[2]

Protein kinase C, epsilon, also known as PRKCE, is a human gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.^[1]

[edit] See also

Protein kinase C

[edit] References

^ Entrez Gene: PRKCE protein kinase C, epsilon.

[edit] Further reading

Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.". Chem. Phys. Lipids 116 (1-2): 75–91. PMID 12093536.
Aksoy E, Goldman M, Willems F (2004). "Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders.". Int. J. Biochem. Cell Biol. 36 (2): 183–8. PMID 14643884.
Tolstrup M, Ostergaard L, Laursen AL, et al. (2004). "HIV/SIV escape from immune surveillance: focus on Nef.". Curr. HIV Res. 2 (2): 141–51. PMID 15078178.