PRKCD

From Wikipedia, the free encyclopedia

See also: Protein kinase C

Protein kinase C, delta
PDB rendering based on 1bdy.
Available structures: 1bdy, 1ptq, 1ptr, 1yrk
Identifiers
Symbol(s)	PRKCD; MAY1; MGC49908; nPKC-delta
External IDs	OMIM: 176977 MGI: 97598 HomoloGene: 55963
Gene ontology Molecular Function: • nucleotide binding • protein serine/threonine kinase activity • diacylglycerol-activated phospholipid-dependent protein kinase C activity • ATP binding • protein C-terminus binding • enzyme activator activity • zinc ion binding • transferase activity • enzyme binding • diacylglycerol binding • metal ion binding Cellular Component: • nucleus • cytoplasm • membrane Biological Process: • protein amino acid phosphorylation • intracellular signaling cascade • immunoglobulin mediated immune response • B cell proliferation • protein stabilization
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5580	18753
Ensembl	ENSG00000163932	ENSMUSG00000021948
Uniprot	Q05655	Q1MX41
Refseq	NM_006254 (mRNA) NP_006245 (protein)	NM_011103 (mRNA) NP_035233 (protein)
Location	Chr 3: 53.17 - 53.2 Mb	Chr 14: 29.42 - 29.44 Mb
Pubmed search	[1]	[2]

Protein kinase C, delta, also known as PRKCD, is a human gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.^[1]

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