PRKCB1

From Wikipedia, the free encyclopedia

Protein kinase C, beta 1

PDB rendering based on 1a25.

Available structures: 1a25, 2i0e

Identifiers

Symbol(s)

PRKCB1; MGC41878; PKC-beta; PKCB; PRKCB; PRKCB2

External IDs

OMIM: 176970 MGI: 97596 HomoloGene: 56424

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase C activity • calcium ion binding • ATP binding • zinc ion binding • transferase activity • diacylglycerol binding
Cellular Component:	• cytoplasm • plasma membrane
Biological Process:	• protein amino acid phosphorylation • intracellular signaling cascade

Orthologs

Human

Mouse

Refseq

NM_002738 (mRNA)
NP_002729 (protein)

NM_008855 (mRNA)
NP_032881 (protein)

Location

Chr 16: 23.75 - 24.14 Mb

Chr 7: 122.08 - 122.42 Mb

Pubmed search

[1]

[2]

Protein kinase C, beta 1, also known as PRKCB1, is a human gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported^[1]. This gene could be associated with autism^[2].

[edit] References

^ Entrez Gene: PRKCB1 protein kinase C, beta 1.
^ Philippi, A; Roschmann, E; Tores, F & Lindenbaum, P (2005), “Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism.”, Mol. Psychiatry 10 (10): 950-604001704, 2005 Oct, PMID :16027742, doi:10.1038/sj.mp.400170416027742, <http://www.ncbi.nlm.nih.gov/pubmed/16027742>

[edit] Further reading

Mochly-Rosen D (1995). "Localization of protein kinases by anchoring proteins: a theme in signal transduction.". Science 268 (5208): 247–51. PMID 7716516.
Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation.". Chem. Rev. 101 (8): 2527–40. PMID 11749387.
Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.". Chem. Phys. Lipids 116 (1-2): 75–91. PMID 12093536.