PRKAR1B

From Wikipedia, the free encyclopedia

Protein kinase, cAMP-dependent, regulatory, type I, beta

Identifiers

External IDs

OMIM: 176911 MGI: 97759 HomoloGene: 37665

Gene ontology
Molecular Function:	• nucleotide binding • cAMP-dependent protein kinase regulator activity • cAMP binding
Cellular Component:	• cAMP-dependent protein kinase complex
Biological Process:	• protein amino acid phosphorylation • signal transduction • learning and/or memory

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_001134041 (mRNA)
XP_001134041 (protein)

NM_008923 (mRNA)
NP_032949 (protein)

Location

n/a

Chr 5: 139.27 - 139.38 Mb

Pubmed search

[1]

[2]

Protein kinase, cAMP-dependent, regulatory, type I, beta, also known as PRKAR1B, is a human gene.^[1]

[edit] References

^ Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta.

[edit] Further reading

Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current drug targets 7 (12): 1595–606. PMID 17168834.
Solberg R, Sistonen P, Träskelin AL, et al. (1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7.". Genomics 14 (1): 63–9. PMID 1358799.
Solberg R, Taskén K, Keiserud A, Jahnsen T (1991). "Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases.". Biochem. Biophys. Res. Commun. 176 (1): 166–72. PMID 1708242.
Hofmann B, Nishanian P, Baldwin RL, et al. (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.". J. Immunol. 145 (11): 3699–705. PMID 1978848.
Scambler P, Oyen O, Wainwright B, et al. (1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.". Am. J. Hum. Genet. 41 (5): 925–32. PMID 3479018.
Hofmann B, Nishanian P, Nguyen T, et al. (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. PMID 7688126.
Solberg R, Taskén K, Wen W, et al. (1994). "Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells.". Exp. Cell Res. 214 (2): 595–605. doi:10.1006/excr.1994.1297. PMID 7925653.
Hofmann B, Nishanian P, Fan J, et al. (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.". AIDS 8 (7): 1016–7. PMID 7946090.
Taskén K, Skålhegg BS, Solberg R, et al. (1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes.". J. Biol. Chem. 268 (28): 21276–83. PMID 8407966.
Swingler S, Gallay P, Camaur D, et al. (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.". J. Virol. 71 (6): 4372–7. PMID 9151826.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.
Zidovetzki R, Wang JL, Chen P, et al. (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.". AIDS Res. Hum. Retroviruses 14 (10): 825–33. PMID 9671211.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184–92. PMID 9730685.
Laxminarayana D, Khan IU, Mishra N, et al. (1999). "Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.". J. Immunol. 162 (9): 5639–48. PMID 10228048.
Adachi M, Lewis EJ (2002). "The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status.". J. Biol. Chem. 277 (25): 22915–24. doi:10.1074/jbc.M201695200. PMID 11943777.
Oliver CJ, Terry-Lorenzo RT, Elliott E, et al. (2002). "Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology.". Mol. Cell. Biol. 22 (13): 4690–701. PMID 12052877.
Nguyen DT, Rovira II, Finkel T (2002). "Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A.". FEBS Lett. 521 (1-3): 170–4. PMID 12067711.
Mucignat-Caretta C, Caretta A (2003). "Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain.". J. Neurocytol. 30 (11): 885–94. PMID 12373096.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Carlson CR, Ruppelt A, Taskén K (2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system.". J. Mol. Biol. 327 (3): 609–18. PMID 12634056.