PRKAG1

From Wikipedia, the free encyclopedia

Protein kinase, AMP-activated, gamma 1 non-catalytic subunit

PDB rendering based on 2uv4.

Available structures: 2uv4, 2uv5, 2uv6, 2uv7

Identifiers

Symbol(s)

PRKAG1; AMPKG; MGC8666

External IDs

OMIM: 602742 MGI: 108411 HomoloGene: 20600

Gene ontology
Molecular Function:	• cAMP-dependent protein kinase activity • kinase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • fatty acid biosynthetic process • signal transduction • spermatogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002733 (mRNA)
NP_002724 (protein)

NM_016781 (mRNA)
NP_058061 (protein)

Location

Chr 12: 47.68 - 47.7 Mb

Chr 15: 98.64 - 98.65 Mb

Pubmed search

[1]

[2]

Protein kinase, AMP-activated, gamma 1 non-catalytic subunit, also known as PRKAG1, is a human gene.^[1]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit.

[edit] Further reading

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Beebe SJ, Oyen O, Sandberg M, et al. (1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.". Mol. Endocrinol. 4 (3): 465–75. PMID 2342480.
Hofmann B, Nishanian P, Nguyen T, et al. (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. PMID 7688126.
Hofmann B, Nishanian P, Fan J, et al. (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.". AIDS 8 (7): 1016–7. PMID 7946090.
Stapleton D, Mitchelhill KI, Gao G, et al. (1996). "Mammalian AMP-activated protein kinase subfamily.". J. Biol. Chem. 271 (2): 611–4. PMID 8557660.
Gao G, Fernandez CS, Stapleton D, et al. (1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase.". J. Biol. Chem. 271 (15): 8675–81. PMID 8621499.
Woods A, Cheung PC, Smith FC, et al. (1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro.". J. Biol. Chem. 271 (17): 10282–90. PMID 8626596.
Dyck JR, Gao G, Widmer J, et al. (1996). "Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits.". J. Biol. Chem. 271 (30): 17798–803. PMID 8663446.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Swingler S, Gallay P, Camaur D, et al. (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.". J. Virol. 71 (6): 4372–7. PMID 9151826.
Stapleton D, Woollatt E, Mitchelhill KI, et al. (1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.". FEBS Lett. 409 (3): 452–6. PMID 9224708.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.
Reinton N, Haugen TB, Orstavik S, et al. (1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon.". Genomics 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.
Zidovetzki R, Wang JL, Chen P, et al. (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.". AIDS Res. Hum. Retroviruses 14 (10): 825–33. PMID 9671211.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184–92. PMID 9730685.
Cheung PC, Salt IP, Davies SP, et al. (2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.". Biochem. J. 346 Pt 3: 659–69. PMID 10698692.
Hamilton SR, Stapleton D, O'Donnell JB, et al. (2001). "An activating mutation in the gamma1 subunit of the AMP-activated protein kinase.". FEBS Lett. 500 (3): 163–8. PMID 11445078.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Minokoshi Y, Alquier T, Furukawa N, et al. (2004). "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.". Nature 428 (6982): 569–74. doi:10.1038/nature02440. PMID 15058305.