Talk:Primidone

From Wikipedia, the free encyclopedia

Primidone is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested editors are welcome.
B This article has been rated as B-Class on the quality scale.
To-do list for Primidone: edit · history · watch · refresh

Here are some tasks you can do:
  • Copyedit: fix every redundant wikilink
  • Merge: Adverse effects sections
  • Verify: That it was Wyeth and that it was released no sooner than 1954.
  • Cleanup: entire article. Gah.
  • Expand: History section, essential tremor section, mechanism of action
  • Other:

    Incorporate the following references somehow:

    Visit the UMKC library to look at the folowing in their print collection:

    Visit the Archie Dykes Library for the following:

    • Stüttgen, G. (March 1973). "Toxic epidermal necrolysis provoked by barbiturates". British Journal of Dermatology 88 (3): 291–3. PubMed. 
    • Mattson, R. H.; J. A. Cramer, J. F. Collins, D. B. Smith, A. V. Delgado-Escueta, T. R. Browne, P. D. Williamson, D. M. Treiman, J. O. McNamara, C. B. McCutchen, et al (July 18, 1985). "Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures". New England Journal of Medicine 313 (3): 145–51. PubMed. 
    • Wilbur, R.; F. A. Kulik (August 1981). "Anticonvulsant drugs in alcohol withdrawal: use of phenytoin, primidone, carbamazepine, valproic acid, and the sedative anticonvulsants". American Journal of Hospital Pharmacy 38 (8): 1138–43. PubMed. 
    • Hermanns, Guido; Soheyl Noachtar, Ingrid Tuxhorn, Hans Holthausen, Alois Ebner, and Peter Wolf (July 1996). "Systematic Testing of Medical Intractability for Carbamazepine, Phenytoin, and Phenobarbital or Primidone in Monotherapy for Patients Considered for Epilepsy Surgery". Epilepsia 37 (7): 675–679. PubMed. 
    • Gorman, W. P.; R. Cooper, P. Pocock, and M. J. Campbell (January 1986). "A comparison of primidone, propranolol, and placebo in essential tremor, using quantitative analysis". Journal of Neurology, Neurosurgery & Psychiatry 49 (1): 64–8. PubMed. 
    • N Not done Skolnick, P.; H. Havoundjian, S. M. Paul (1987). "Modulation of the benzodiazepine-GABA receptor chloride ionophore complex by multiple allosteric sites: evidence for a barbiturate 'receptor'". Psychopharmacology Series 3: 29–36. PubMed. 
    • MacDonald, R. L.; K. M. Kelly (1995). "Antiepileptic drug mechanisms of action". Epilepsia 36 (Suppl 2): S2–12. PubMed. 
    • DeSilvey DL; Moss AJ (July 1980). "Primidone in the treatment of the long QT syndrome: QT shortening and ventricular arrhythmia suppression". Annals of Internal Medicine 93 (1): 53–4. PubMed. 
    • Baker H., H.; O. Frank, S. H. Hutner, S. Aaronson, H. Ziffer, H. Sobotka. (May 15, 1962). "Lesions in folic acid metabolism induced by primidone". Experientia 18: 224–6. PubMed. 
    • Rodin, Ernst A.; Rim CS, Kitano H, Lewis R, Rennick PM (1976). "A comparison of the effectiveness of primidone versus carbamazepine in epileptic outpatients". The Journal of Nervous and Mental Disease 163 (1): 41–6. PubMed. 
    • Girdwood, R. H. (1976). "Drug-induced anaemias". Drugs 11 (5): 394–404. PubMed. 
    • Mattson, R. H. (December 1990). "Selection of drugs for the treatment of epilepsy". Seminars in Neurology 10 (4): 406-13. PubMed. 
    • N Not done Kagitani-Shimono, Kuriko; Imai Katsumi, Okamoto Nobuhiko, Ono Jiro and Okada Shintaro (January 2002). "Unverricht-Lundborg disease with cystatin B gene abnormalities". Pediatric Neurology 26 (1): 55–60. PubMed. 
    • Monroe, R. R. (February 1975). "Anticonvulsants in the treatment of aggression". Journal of Nervous and Mental Disease 160 (2–1): 119–26. PubMed. 
    • Calzetti, S.; L. J. Findley, F. Pisani and A. Richens (October 1981). "Phenylethylmalonamide in essential tremor. A double-blind controlled study". Journal of Neurology, Neurosurgery, and Psychiatry 44 (10): 932-934. PubMed. 
    • N Not done Critchley EM, Vakil SD, Hayward HW, Owen VM (1976). "Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants". Journal of Neurology, Neurosurgery, and Psychiatry 39 (5): 498-503. PubMed. 
    • Reynolds, Jr., N. C.; Miska, R. M. (April 1981). "Safety of anticonvulsants in hepatic porphyrias". Neurology 31 (4): 480-4. PubMed. 
    • Stores, G. (October 1975). "Behavioural effects of anti-epileptic drugs". Developmental Medicine and Child Neurology 17 (5): 647-58. PubMed. 
    • Theis JG, Koren G, Daneman R, Sherwin AL, Menzano E, Cortez M, Hwang P (1997). "Interactions of clobazam with conventional antiepileptics in children". Journal of Child Neurology 12 (3): 208–13. PubMed. 
    • Browne, Thomas R.; Robert G. Feldman, Robert A. Buchanan RA, Nancy C. Allen, L. Fawcett-Vickers, GK Szabo, GF Mattson, SE Norman, DJ Greenblatt (April 1983). "Methsuximide for complex partial seizures: efficacy, toxicity, clinical pharmacology, and drug interactions". Neurology 33 (4): 414–8. PubMed. 
    • Spina, Edoardo; Francesco Pisani, and Emilio Perucca (September 1996). "Clinically significant pharmacokinetic drug interactions with carbamazepine. An update.". Clinical Pharmacokinetics 31 (3): 198–214. PubMed. 
    • Young MC, Hughes IA (1991). "Loss of therapeutic control in congenital adrenal hyperplasia due to interaction between dexamethasone and primidone.". Acta Paediatrica Scandinavica 80 (1): 120-4. PMID 2028784. 
    • Tempelhoff, Rene; P. A. Modica and Edward L. Spitznagel, Jr. (April 1990). "Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy". Canadian Journal of Anaesthesia / Journal Canadien D'Anesthésie 37 (3): 327–32. PubMed. 
    • Alvin J; Goh E, Bush MT (July 1975). "Study of the hepatic metabolism of primidone by improved methodology". Journal of Pharmacology and Experimental Therapeutics 194 (1): 117-25. PubMed. 
    • Hooper WD; Treston AM, Jacobsen NW, Dickinson RG, Eadie MJ (November/December 1983). "Identification of p-hydroxyprimidone as a minor metabolite of primidone in rat and man". Drug Metabolism and Disposition 11 (6): 607–10. PubMed. 
    • N Not done Li, Chien-Chun; Chong-Kuei Lii, Kai-Li Liu, Jaw-Ji Yang, and Haw-Wen Chen (August 23, 2007). "DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation". Toxicology and Applied Pharmacology. doi:10.1016/j.taap.2007.08.009. PubMed. 
    • Martines C, Gatti G, Sasso E, Calzetti S, Perucca E. (1990). "The disposition of primidone in elderly patients.". British Journal of Clinical Pharmacology 30 (4): 607–11. PubMed. 
    • van Heijst, A. N.; W. de Jong, R. Seldenrijk, A. van Dijk (June 1983). "Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion". Journal of Toxicology. Clinical Toxicology 20 (4): 307–18. PubMed. 
    • Bailey, D. N.; P. I. Jatlow (November 1972). "Chemical analysis of massive crystalluria following primidone overdose". American Journal of Clinical Pathology 58 (5): 583–9. PubMed. 
    • Brillman, J.; B. B. Gallagher, and R. H. Mattson (March 1974). "Acute primidone intoxication". Archives of Neurology 30 (3): 255–8. PubMed. 
    • Turner, C. R. (October 1980). "Primidone intoxication and massive crystalluria". Clinical Pediatrics 19 (10): 706–7. PubMed. 
    • Kappy, M. S.; J. Buckley (April 1969). "Primidone intoxication in a child". Archives of Disease in Childhood 44 (234): 282–4. PubMed. 
    • Ajax, E. T. (October 1966). "An unusual case of primidone intoxication". Diseases of the Nervous System 27 (10): 660–1. PubMed. 
    • White, P. T.; Plott D, and Norton J (January 1966). "Relative anticonvulsant potency of primidone; a double blind comparison". Archives of Neurology 14 (1): 31–5. PubMed. 
    • Sasso, Enrico; Emilio Perucca, and Stefano Calzetti (May 1988). "Double-blind comparison of primidone and phenobarbital in essential tremor". Neurology 38 (5): 808–10. PubMed. 
    • Sasso, Enrico; Emilio Perrucca, R. Fava, and Stefano Calzetti (1991). "Quantitative comparison of barbiturates in essential hand and head tremor". Movement Disorders 6 (1): 65–8. PubMed. 
    • Livingston, S.; D. Petersen (February 16, 1956). "Primidone (mysoline) in the treatment of epilepsy; results of treatment of 486 patients and review of the literature". New England Journal of Medicine 254 (7): 327–9. PubMed. 
    • Thorn, I. (June 1962). "Primidone and chlordiazepoxide in cerebral palsy". Developmental Medicine and Child Neurology 4: 325–7. PubMed. 
    • Sher, A.; J. M. Andersen, and S. C. Bhatia (July-August 1983). "Primidone-induced catatonic schizophrenia". Drug Intelligence & Clinical Pharmacy 17 (7–8): 551–2. PubMed. 
    • "International glossary of antiepileptic drugs" (1992). Epilepsia 33 (Suppl 2): 1–193. PubMed. 
    • N Not done Findley, L. J. (1986). "The pharmacological management of essential tremor". Clinical Neuropharmacology 9 (Suppl 2): S61–75. PubMed. 
    • Herranz, J. L.; J. A. Armijo, and R. Arteaga (November-December 1988). "Clinical side effects of phenobarbital, primidone, phenytoin, carbamazepine, and valproate during monotherapy in children". Epilepsia 29 (6): 794–804. PubMed. 
    • Smith, D. B.; Richard H. Mattson, J. A. Cramer, J. F. Collins, R. A. Novelly, and B. Craft (1987). "Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone". Epilepsia 28 (Suppl 3): S50-8. PubMed. 
    • Gruber, C. M., Jr.; J. T. Brock, and M. Dyken (January-February 1962). "Comparison of the effectiveness of phenobarital, mephobarbital, primidone, diphenylhydantoin, ethotoin, metharbital, and methylphenylethylhydantoin in motor seizures". Clinical Pharmacology and Therapeutics 3: 23–8. PubMed. 
Priority 3  

[edit] Side Effects

One of my friends reports that he was given this drug and now his hands tremble so badly that he can no longer do the artwork he used to enjoy doing. I don't see this side effect being reported on the main page. —Preceding unsigned comment added by 71.167.163.124 (talk) 18:28, 25 May 2008 (UTC)