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| HIV primer binding site (PBS) |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Predicted; PFOLD; |
| Seed alignment: |
PubMed |
| Avg length: |
94.8 nucleotides |
| Avg identity: |
79% |
|
The primer binding site is a structured RNA element in the genomes of retroviruses to which tRNA(3)(Lys) binds to initiate reverse transcription [2]. It consists of 18 nucleotides and follows the U5 region of the 5'-long terminal repeat (LTR) of the retrovirus.
[edit] References
- [1] Damgaard, CK; Andersen ES, Knudsen B, Gorodkin J, Kjems J (2004). "RNA interactions in the 5' region of the HIV-1 genome". J Mol Biol 336: 369–379. doi:10.1016/j.jmb.2003.12.010. PMID 14757051.
- [2] Beerens, N; Groot F, Berkhout B (2001). "Initiation of HIV-1 reverse transcription is regulated by a primer activation signal". J Biol Chem 276: 31247–31256. doi:10.1074/jbc.M102441200. PMID 11384976.
[edit] External links
