PRIC285

From Wikipedia, the free encyclopedia

Peroxisomal proliferator-activated receptor A interacting complex 285

Identifiers

PRIC285; FLJ00244; KIAA1769; MGC132634; MGC138228; PDIP-1; PDIP1beta

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • DNA binding • transcription coactivator activity • RNA binding • helicase activity • ribonuclease activity • ATP binding • zinc ion binding • hydrolase activity • nucleoside-triphosphatase activity • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

n/a

Refseq

NM_001037335 (mRNA)
NP_001032412 (protein)

XM_001001060 (mRNA)
XP_001001060 (protein)

Location

Chr 20: 61.66 - 61.68 Mb

Chr 2: 181.16 - 181.17 Mb

Pubmed search

[1]

[2]

Peroxisomal proliferator-activated receptor A interacting complex 285, also known as PRIC285, is a human gene.^[1]

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. PMID 11214970.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. doi:10.1073/pnas.182426699. PMID 12189208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma.". Endocrinology 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.