PRG4

From Wikipedia, the free encyclopedia


Proteoglycan 4
Identifiers
Symbol(s) PRG4; MSF; CACP; FLJ32635; HAPO; JCAP; SZP; bG174L6.2
External IDs OMIM: 604283 HomoloGene: 4242
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10216 n/a
Ensembl ENSG00000116690 n/a
Uniprot Q92954 n/a
Refseq NM_005807 (mRNA)
NP_005798 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 1: 184.53 - 184.55 Mb n/a
Pubmed search [1] n/a

Proteoglycan 4, also known as PRG4, is a human gene.[1]

The protein encoded by this gene is an approximately 345-kD proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. The cDNA encodes a protein of 1,404 amino acids with a somatomedin B homology domain, heparin-binding domains, multiple mucin-like repeats, a hemopexin domain, and an aggregation domain. There are 3 consensus sequences for N-glycosylation and 1 chondroitin sulfate substitution site. The locus for autosomal recessive camptodactyly-arthropathy-coxa vara-pericarditis syndrome maps to chromosome 1q25-q31. This protein may act as a joint/intimal cell lubricant, and cell overgrowth may be primary to the pathogenesis of this protein.[1]

[edit] References

  1. ^ a b Entrez Gene: PRG4 proteoglycan 4.

[edit] Further reading

  • Schumacher BL, Block JA, Schmid TM, et al. (1994). "A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage.". Arch. Biochem. Biophys. 311 (1): 144-52. doi:10.1006/abbi.1994.1219. PMID 8185311. 
  • Bahabri SA, Suwairi WM, Laxer RM, et al. (1998). "The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1.". Arthritis Rheum. 41 (4): 730-5. doi:10.1002/1529-0131(199804)41:4<730::AID-ART22>3.0.CO;2-Y. PMID 9550484. 
  • Flannery CR, Hughes CE, Schumacher BL, et al. (1999). "Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism.". Biochem. Biophys. Res. Commun. 254 (3): 535-41. doi:10.1006/bbrc.1998.0104. PMID 9920774. 
  • Marcelino J, Carpten JD, Suwairi WM, et al. (1999). "CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome.". Nat. Genet. 23 (3): 319-22. doi:10.1038/15496. PMID 10545950. 
  • Jay GD, Britt DE, Cha CJ (2000). "Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts.". J. Rheumatol. 27 (3): 594-600. PMID 10743795. 
  • Ikegawa S, Sano M, Koshizuka Y, Nakamura Y (2001). "Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes.". Cytogenet. Cell Genet. 90 (3-4): 291-7. PMID 11124536. 
  • Rees SG, Davies JR, Tudor D, et al. (2003). "Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon.". Matrix Biol. 21 (7): 593-602. PMID 12475643. 
  • Morawietz L, Gehrke T, Frommelt L, et al. (2003). "Differential gene expression in the periprosthetic membrane: lubricin as a new possible pathogenetic factor in prosthesis loosening.". Virchows Arch. 443 (1): 57-66. doi:10.1007/s00428-003-0818-y. PMID 12783322. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Liu YJ, Lu SH, Xu B, et al. (2004). "Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages.". Blood 103 (12): 4449-56. doi:10.1182/blood-2003-06-1825. PMID 14976050. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • de Haan G (2006). "A novel growth factor encoded by an old gene.". Haematologica 90 (2): 152. PMID 15710563. 
  • Rhee DK, Marcelino J, Al-Mayouf S, et al. (2005). "Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.". J. Biol. Chem. 280 (35): 31325-32. doi:10.1074/jbc.M505401200. PMID 16000300. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952. 
  • Alazami AM, Al-Mayouf SM, Wyngaard CA, Meyer B (2006). "Novel PRG4 mutations underlie CACP in Saudi families.". Hum. Mutat. 27 (2): 213. doi:10.1002/humu.9399. PMID 16429407. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414. 
  • Zhang D, Johnson LJ, Hsu HP, Spector M (2007). "Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage.". J. Orthop. Res. 25 (7): 873-83. doi:10.1002/jor.20344. PMID 17343281. 
  • Jay GD, Torres JR, Warman ML, et al. (2007). "The role of lubricin in the mechanical behavior of synovial fluid.". Proc. Natl. Acad. Sci. U.S.A. 104 (15): 6194-9. doi:10.1073/pnas.0608558104. PMID 17404241. 
 This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.