Precorrin-2 dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a precorrin-2 dehydrogenase (EC 1.3.1.76) is an enzyme that catalyzes the chemical reaction

precorrin-2 + NAD⁺ sirohydrochlorin + NADH + H⁺

Thus, the two substrates of this enzyme are precorrin 2 and NAD⁺, whereas its 3 products are sirohydrochlorin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is precorrin-2:NAD+ oxidoreductase. Other names in common use include Met8p, SirC, and CysG. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

• IUBMB entry for 1.3.1.76
• BRENDA references for 1.3.1.76 (Recommended.)
• PubMed references for 1.3.1.76
• PubMed Central references for 1.3.1.76
• Google Scholar references for 1.3.1.76
• Warren MJ (2002). "The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase". EMBO. J. 21: 2068–75. doi:10.1093/emboj/21.9.2068. PMID 11980703. 
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810. 

[edit] External links

• IUBMB entry for 1.3.1.76

• KEGG entry for 1.3.1.76

• BRENDA entry for 1.3.1.76

• NiceZyme view of 1.3.1.76

• EC2PDB: PDB structures for 1.3.1.76

• PRIAM entry for 1.3.1.76

• PUMA2 entry for 1.3.1.76

• IntEnz: Integrated Enzyme entry for 1.3.1.76

• MetaCyc entry for 1.3.1.76

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043115: precorrin-2 dehydrogenase

• AMIGO entry for GO code 0043115: precorrin-2 dehydrogenase