PreQ1 synthase

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In enzymology, a preQ1 synthase (EC 1.7.1.13) is an enzyme that catalyzes the chemical reaction

7-aminomethyl-7-carbaguanine + 2 NADP⁺ $\rightleftharpoons$ 7-cyano-7-carbaguanine + 2 NADPH + 2 H⁺

Thus, the two substrates of this enzyme are 7-aminomethyl-7-carbaguanine and NADP⁺, whereas its 3 products are 7-cyano-7-carbaguanine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase. Other names in common use include YkvM, QueF, preQ0 reductase, preQ0 oxidoreductase, 7-cyano-7-deazaguanine reductase, 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase, queuine synthase (incorrect as queuine is not the product), queuine:NADP+ oxidoreductase (incorrect as queuine is not the, and product).

[edit] References

IUBMB entry for 1.7.1.13
BRENDA references for 1.7.1.13 (Recommended.)
PubMed references for 1.7.1.13
PubMed Central references for 1.7.1.13
Google Scholar references for 1.7.1.13
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Nishimura S (1978). "Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine". Nucleic. Acids. Res. 5: 4215–23. doi:10.1093/nar/5.11.4215. PMID 364423.
V, Iwata-Reuyl D, Schimmel P (2005). "Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme". Acta. Crystallograph. Sect. F. Struct. Biol. Cryst. Commun. 61: 945–8. doi:10.1107/S1744309105029246. PMID 16511203.