PreQ1-II riboswitch

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PreQ1-II riboswitches form a class of riboswitches that specifically bind pre-queosine1 (PreQ1), a precursor of the modified nucleoside queuosine[1]. They are found in certain species of Streptococcus and Lactococcus, and were originally identified as a conserved RNA secondary structure called the "COG4708 motif"[2]. All known members of this riboswitch class appear to control members of COG4708 genes. These genes are predicted to encode membrane-bound proteins and have been proposed to be a transporter of preQ1, or a related metabolite, based on their association with preQ1-binding riboswitches[1]. PreQ1-II riboswitches have no apparent similarities in sequence or structure to preQ1-I riboswitches, a previously discovered class of preQ1-binding riboswitches. PreQ1 thus joins S-adenosylmethionine as the second metabolite to be found that is the ligand of more than one riboswitch class.

[edit] References

  1. ^ a b Meyer MM, Roth A, Chervin SM, Garcia GA, Breaker RR (2008). "Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria". RNA. doi:10.1261/rna.937308. PMID 18305186. 
  2. ^ Weinberg Z, Barrick JE, Yao Z, et al (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–19. doi:10.1093/nar/gkm487. PMID 17621584. 
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