PREX1

From Wikipedia, the free encyclopedia

Phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1

Identifiers

PREX1; KIAA1415

External IDs

OMIM: 606905 MGI: 3040696 HomoloGene: 10821

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • Rho GTPase activator activity • phospholipid binding • enzyme binding
Cellular Component:	• intracellular • cytosol • plasma membrane
Biological Process:	• superoxide metabolic process • intracellular signaling cascade • actin filament polymerization • regulation of Rho protein signal transduction • neutrophil activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_020820 (mRNA)
NP_065871 (protein)

XM_485102 (mRNA)
XP_485102 (protein)

Location

Chr 20: 46.67 - 46.88 Mb

Chr 2: 166.26 - 166.41 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1, also known as PREX1, is a human gene.^[1]

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: PREX1 phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.". Genomics 76 (1-3): 45-57. doi:10.1006/geno.2001.6584. PMID 11549316.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Welch HC, Coadwell WJ, Ellson CD, et al. (2002). "P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.". Cell 108 (6): 809-21. PMID 11955434.
Weiner OD (2002). "Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?". Curr. Biol. 12 (12): R429-31. PMID 12123595.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hill K, Krugmann S, Andrews SR, et al. (2005). "Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.". J. Biol. Chem. 280 (6): 4166-73. doi:10.1074/jbc.M411262200. PMID 15545267.
Mayeenuddin LH, Garrison JC (2006). "Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity.". J. Biol. Chem. 281 (4): 1921-8. doi:10.1074/jbc.M506035200. PMID 16301320.
Zhao T, Nalbant P, Hoshino M, et al. (2007). "Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.". J. Leukoc. Biol. 81 (4): 1127-36. doi:10.1189/jlb.0406251. PMID 17227822.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, et al. (2007). "P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.". J. Biol. Chem. 282 (32): 23708-15. doi:10.1074/jbc.M703771200. PMID 17565979.
Barber MA, Donald S, Thelen S, et al. (2007). "Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.". J. Biol. Chem. 282 (41): 29967-76. doi:10.1074/jbc.M701877200. PMID 17698854.