PREB

From Wikipedia, the free encyclopedia

Prolactin regulatory element binding

Identifiers

PREB; MGC3467; SEC12

External IDs

OMIM: 606395 MGI: 1355326 HomoloGene: 40877

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleus • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• transcription • regulation of transcription, DNA-dependent • ER to Golgi vesicle-mediated transport • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013388 (mRNA)
NP_037520 (protein)

NM_016703 (mRNA)
NP_057912 (protein)

Location

Chr 2: 27.21 - 27.21 Mb

Chr 5: 31.23 - 31.35 Mb

Pubmed search

[1]

[2]

Prolactin regulatory element binding, also known as PREB, is a human gene.^[1]

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.^[1]

[edit] References

^ ^a ^b Entrez Gene: PREB prolactin regulatory element binding.

[edit] Further reading

Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Edgar AJ (2003). "The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12.". BMC Genomics 4 (1): 18. doi:10.1186/1471-2164-4-18. PMID 12735795.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Taylor Clelland CL, Levy B, McKie JM, et al. (2000). "Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome.". Mamm. Genome 11 (8): 675-81. PMID 10920239.
Fliss MS, Hinkle PM, Bancroft C (1999). "Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity.". Mol. Endocrinol. 13 (4): 644-57. PMID 10194769.