PRDM1

From Wikipedia, the free encyclopedia


PR domain containing 1, with ZNF domain
Identifiers
Symbol(s) PRDM1; BLIMP1; MGC118922; MGC118923; MGC118924; MGC118925; PRDI-BF1
External IDs OMIM: 603423 MGI: 99655 HomoloGene: 925
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 639 12142
Ensembl ENSG00000057657 ENSMUSG00000038151
Uniprot O75626 Q3UET9
Refseq NM_001198 (mRNA)
NP_001189 (protein)		 NM_007548 (mRNA)
NP_031574 (protein)
Location Chr 6: 106.64 - 106.66 Mb Chr 10: 44.13 - 44.15 Mb
Pubmed search [1] [2]

PR domain containing 1, with ZNF domain, also known as PRDM1, is a human gene.[1]

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain.

[edit] Further reading

  • Keller AD, Maniatis T (1991). "Identification and characterization of a novel repressor of beta-interferon gene expression.". Genes Dev. 5 (5): 868–79. PMID 1851123. 
  • Huang S (1994). "Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1.". Cell 78 (1): 9. PMID 8033216. 
  • Turner CA, Mack DH, Davis MM (1994). "Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells.". Cell 77 (2): 297–306. PMID 8168136. 
  • Mock BA, Liu L, LePaslier D, Huang S (1997). "The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10.". Genomics 37 (1): 24–8. PMID 8921366. 
  • Ren B, Chee KJ, Kim TH, Maniatis T (1999). "PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins.". Genes Dev. 13 (1): 125–37. PMID 9887105. 
  • Angelin-Duclos C, Cattoretti G, Lin KI, Calame K (2000). "Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo.". J. Immunol. 165 (10): 5462–71. PMID 11067898. 
  • Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins.". J. Immunol. 166 (10): 6104–11. PMID 11342629. 
  • Medina F, Segundo C, Campos-Caro A, et al. (2002). "The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression.". Blood 99 (6): 2154–61. PMID 11877292. 
  • Shaffer AL, Lin KI, Kuo TC, et al. (2002). "Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program.". Immunity 17 (1): 51–62. PMID 12150891. 
  • Vasanwala FH, Kusam S, Toney LM, Dent AL (2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene.". J. Immunol. 169 (4): 1922–9. PMID 12165517. 
  • Borson ND, Lacy MQ, Wettstein PJ (2003). "Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma.". Blood 100 (13): 4629–39. doi:10.1182/blood.V100.13.4629. PMID 12453881. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Györy I, Fejér G, Ghosh N, et al. (2003). "Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines.". J. Immunol. 170 (6): 3125–33. PMID 12626569. 
  • Gyory I, Wu J, Fejér G, et al. (2004). "PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing.". Nat. Immunol. 5 (3): 299–308. doi:10.1038/ni1046. PMID 14985713. 
  • Lotz C, Mutallib SA, Oehlrich N, et al. (2005). "Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL.". J. Immunol. 175 (2): 1301–9. PMID 16002735. 
  • Tam W, Gomez M, Chadburn A, et al. (2006). "Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas.". Blood 107 (10): 4090–100. doi:10.1182/blood-2005-09-3778. PMID 16424392. 
  • Pasqualucci L, Compagno M, Houldsworth J, et al. (2006). "Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma.". J. Exp. Med. 203 (2): 311–7. doi:10.1084/jem.20052204. PMID 16492805. 
  • González-García I, Ocaña E, Jiménez-Gómez G, et al. (2006). "Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells.". J. Immunol. 176 (7): 4042–50. PMID 16547239. 
  • Garcia JF, Roncador G, García JF, et al. (2006). "PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma.". Haematologica 91 (4): 467–74. PMID 16585013. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 

[edit] External links


 This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD