PRB4

From Wikipedia, the free encyclopedia

Proline-rich protein BstNI subfamily 4

Identifiers

External IDs

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • molecular_function
Cellular Component:	• extracellular region • extracellular space • integral to membrane
Biological Process:	• G-protein coupled receptor protein signaling pathway • biological_process

Orthologs

Human

Mouse

Entrez

5545

n/a

Refseq

NM_002723 (mRNA)
NP_002714 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Proline-rich protein BstNI subfamily 4, also known as PRB4, is a human gene.^[1]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4.

[edit] Further reading

Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms.". Adv. Hum. Genet. 17: 141–99. PMID 3055850.
Bennick A (1982). "Salivary proline-rich proteins.". Mol. Cell. Biochem. 45 (2): 83–99. PMID 6810092.
Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.". Genetics 120 (1): 267–78. PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.
Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci.". Genetics 120 (1): 255–65. PMID 3220251.
Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract.". Am. Rev. Respir. Dis. 130 (1): 115–8. PMID 6377992.
Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva.". J. Biochem. 93 (2): 495–502. PMID 6841349.
Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins.". Crit. Rev. Oral Biol. Med. 4 (3-4): 287–92. PMID 8373986.
Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family.". Mamm. Genome 4 (1): 3–14. PMID 8422499.
Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.". Am. J. Hum. Genet. 58 (1): 143–53. PMID 8554050.
Castle AM, Castle JD (1998). "Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein.". Mol. Biol. Cell 9 (3): 575–83. PMID 9487127.
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases.". Eur. J. Biochem. 268 (12): 3423–31. PMID 11422372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance.". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201.