PRB1

From Wikipedia, the free encyclopedia

Proline-rich protein BstNI subfamily 1

Identifiers

PRB1; PM; PMF; PMS; PRB1L; PRB1M; Ps 1; Ps 2; PRPPRB1; Ps; cP7

External IDs

OMIM: 180989 MGI: 2681872 HomoloGene: 74537

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • molecular_function
Cellular Component:	• extracellular region • integral to membrane • cellular_component
Biological Process:	• G-protein coupled receptor protein signaling pathway • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005039 (mRNA)
NP_005030 (protein)

XM_904800 (mRNA)
XP_909893 (protein)

Location

Chr 12: 11.44 - 11.44 Mb

Chr 6: 132.08 - 132.18 Mb

Pubmed search

[1]

[2]

Proline-rich protein BstNI subfamily 1, also known as PRB1, is a human gene.^[1]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1.

[edit] Further reading

Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms.". Adv. Hum. Genet. 17: 141–99. PMID 3055850.
Bennick A (1982). "Salivary proline-rich proteins.". Mol. Cell. Biochem. 45 (2): 83–99. PMID 6810092.
Ikemoto S, Minaguchi K, Suzuki K, Tomita K (1977). "New Genetic marker in human parotid saliva (pm).". Science 197 (4301): 378–9. PMID 877561.
Castle AM, Stahl LE, Castle JD (1992). "A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum.". J. Biol. Chem. 267 (18): 13093–100. PMID 1618808.
Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.". Genetics 120 (1): 267–78. PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.
Kauffman D, Hofmann T, Bennick A, Keller P (1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6.". Biochemistry 25 (9): 2387–92. PMID 3521730.
Azen E, Lyons KM, McGonigal T, et al. (1984). "Clones from the human gene complex coding for salivary proline-rich proteins.". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5561–5. PMID 6089212.
Saitoh E, Isemura S, Sanada K (1984). "Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H.". J. Biochem. 94 (6): 1991–9. PMID 6671974.
Kauffman D, Wong R, Bennick A, Keller P (1983). "Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair.". Biochemistry 21 (25): 6558–62. PMID 6924859.
Isemura S, Saitoh E, Sanada K (1982). "Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E.". J. Biochem. 91 (6): 2067–75. PMID 7118863.
Azen EA, Latreille P, Niece RL (1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs).". Am. J. Hum. Genet. 53 (1): 264–78. PMID 8317492.
Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family.". Mamm. Genome 4 (1): 3–14. PMID 8422499.
Castle AM, Castle JD (1998). "Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein.". Mol. Biol. Cell 9 (3): 575–83. PMID 9487127.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases.". Eur. J. Biochem. 268 (12): 3423–31. PMID 11422372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.