PRAM1

From Wikipedia, the free encyclopedia


PML-RARA regulated adaptor molecule 1
Identifiers
Symbol(s) PRAM1; MGC39864; PRAM-1
External IDs OMIM: 606466 MGI: 3576625 HomoloGene: 12963
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 84106 378460
Ensembl ENSG00000133246 ENSMUSG00000032739
Uniprot Q96QH2 Q6BCL1
Refseq NM_032152 (mRNA)
NP_115528 (protein)		 NM_001002842 (mRNA)
NP_001002842 (protein)
Location Chr 19: 8.46 - 8.47 Mb Chr 17: 33.25 - 33.25 Mb
Pubmed search [1] [2]

PML-RARA regulated adaptor molecule 1, also known as PRAM1, is a human gene.[1]

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).[1]

[edit] References

  1. ^ a b Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1.

[edit] Further reading

  • Boddy MN, Howe K, Etkin LD, et al. (1996). "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.". Oncogene 13 (5): 971–82. PMID 8806687. 
  • Cao T, Duprez E, Borden KL, et al. (1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.". J. Cell. Sci. 111 ( Pt 10): 1319–29. PMID 9570750. 
  • Moog-Lutz C, Peterson EJ, Lutz PG, et al. (2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells.". J. Biol. Chem. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322. 
  • Khan MM, Nomura T, Kim H, et al. (2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.". Mol. Cell 7 (6): 1233–43. PMID 11430826. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Clemens RA, Newbrough SA, Chung EY, et al. (2004). "PRAM-1 is required for optimal integrin-dependent neutrophil function.". Mol. Cell. Biol. 24 (24): 10923–32. doi:10.1128/MCB.24.24.10923-10932.2004. PMID 15572693. 
  • Denis FM, Benecke A, Di Gioia Y, et al. (2005). "PRAM-1 potentiates arsenic trioxide-induced JNK activation.". J. Biol. Chem. 280 (10): 9043–8. doi:10.1074/jbc.M413564200. PMID 15637062. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Rossi V, Levati L, Biondi A (2006). "Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR.". Methods Mol. Med. 125: 115–26. PMID 16502581. 
  • Mokany E, Todd AV, Fuery CJ, Applegate TL (2006). "Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR.". Methods Mol. Med. 125: 127–47. PMID 16502582. 
  • Heuer K, Sylvester M, Kliche S, et al. (2006). "Lipid-binding hSH3 domains in immune cell adapter proteins.". J. Mol. Biol. 361 (1): 94–104. doi:10.1016/j.jmb.2006.06.004. PMID 16831444. 
 This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.