PPM1G

From Wikipedia, the free encyclopedia

Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform

Identifiers

PPM1G; MGC1675; MGC2870; PP2CG; PP2CGAMMA; PPP2CG

External IDs

OMIM: 605119 MGI: 106065 HomoloGene: 31106

Gene ontology
Molecular Function:	• magnesium ion binding • catalytic activity • protein phosphatase type 2C activity • hydrolase activity • manganese ion binding
Cellular Component:	• nucleus • protein serine/threonine phosphatase complex
Biological Process:	• protein amino acid dephosphorylation • cell cycle arrest

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002707 (mRNA)
NP_002698 (protein)

NM_008014 (mRNA)
NP_032040 (protein)

Location

Chr 2: 27.46 - 27.49 Mb

Chr 5: 31.48 - 31.5 Mb

Pubmed search

[1]

[2]

Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, also known as PPM1G, is a human gene.^[1]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: PPM1G protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform.

[edit] Further reading

Guthridge MA, Bellosta P, Tavoloni N, Basilico C (1997). "FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression.". Mol. Cell. Biol. 17 (9): 5485–98. PMID 9271424.
Travis SM, Welsh MJ (1997). "PP2C gamma: a human protein phosphatase with a unique acidic domain.". FEBS Lett. 412 (3): 415–9. PMID 9276438.
Murray MV, Kobayashi R, Krainer AR (1999). "The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor.". Genes Dev. 13 (1): 87–97. PMID 9887102.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Flajolet M, Rakhilin S, Wang H, et al. (2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. PMID 14663150.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Maynes JT, Luu HA, Cherney MM, et al. (2006). "Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins.". J. Mol. Biol. 356 (1): 111–20. doi:10.1016/j.jmb.2005.11.019. PMID 16343532.
Suh EJ, Kim TY, Kim SH (2007). "PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1).". FEBS Lett. 580 (26): 6100–4. doi:10.1016/j.febslet.2006.10.005. PMID 17054950.
Kimura H, Takizawa N, Allemand E, et al. (2006). "A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.". J. Cell Biol. 175 (3): 389–400. doi:10.1083/jcb.200608001. PMID 17074886.
Luo W, Peterson A, Garcia BA, et al. (2007). "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.". EMBO J. 26 (6): 1511–21. doi:10.1038/sj.emboj.7601607. PMID 17318175.
Allemand E, Hastings ML, Murray MV, et al. (2007). "Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.". Nat. Struct. Mol. Biol. 14 (7): 630–8. doi:10.1038/nsmb1257. PMID 17572683.
Petri S, Grimmler M, Over S, et al. (2007). "Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex.". J. Cell Biol. 179 (3): 451–65. doi:10.1083/jcb.200704163. PMID 17984321.