PPIE (gene)

From Wikipedia, the free encyclopedia

Peptidylprolyl isomerase E (cyclophilin E)

PDB rendering based on 1zcx.

Available structures: 1zcx, 1zmf, 2cqb

Identifiers

Symbol(s)

PPIE; CYP-33; MGC111222; MGC3736

External IDs

OMIM: 602435 MGI: 1917118 HomoloGene: 38142

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding • peptidyl-prolyl cis-trans isomerase activity • protein binding • cyclosporin A binding • isomerase activity
Cellular Component:	• nucleus • spliceosome
Biological Process:	• mRNA processing • protein folding • RNA splicing • regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006112 (mRNA)
NP_006103 (protein)

NM_019489 (mRNA)
NP_062362 (protein)

Location

Chr 1: 39.98 - 40 Mb

Chr 4: 122.63 - 122.64 Mb

Pubmed search

[1]

[2]

Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is a human gene.^[1]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities and also exhibit RNA-binding activity. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.^[1]

[edit] References

^ ^a ^b Entrez Gene: PPIE peptidylprolyl isomerase E (cyclophilin E).

[edit] Further reading

Mi H, Kops O, Zimmermann E, et al. (1997). "A nuclear RNA-binding cyclophilin in human T cells.". FEBS Lett. 398 (2-3): 201–5. PMID 8977107.
Kim JO, Nau MM, Allikian KA, et al. (1998). "Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines.". Oncogene 17 (8): 1019–26. doi:10.1038/sj.onc.1202006. PMID 9747881.
Fair K, Anderson M, Bulanova E, et al. (2001). "Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells.". Mol. Cell. Biol. 21 (10): 3589–97. doi:10.1128/MCB.21.10.3589-3597.2001. PMID 11313484.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.