POU4F3

From Wikipedia, the free encyclopedia

POU domain, class 4, transcription factor 3

Identifiers

POU4F3; BRN3C; DFNA15; MGC138412

External IDs

OMIM: 602460 MGI: 102523 HomoloGene: 2023

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter • nervous system development • visual perception • sensory perception of sound • hair cell differentiation • inner ear morphogenesis • regulation of balance • neuron apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002700 (mRNA)
NP_002691 (protein)

NM_138945 (mRNA)
NP_620395 (protein)

Location

Chr 5: 145.7 - 145.7 Mb

Chr 18: 42.52 - 42.52 Mb

Pubmed search

[1]

[2]

POU domain, class 4, transcription factor 3, also known as POU4F3, is a human gene.^[1]

[edit] References

^ Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3.

[edit] Further reading

Nolan LS, Jagutpal SS, Cadge BA, et al. (2007). "Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.". Gene 400 (1-2): 89-97. doi:10.1016/j.gene.2007.05.023. PMID 17611044.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Clough RL, Sud R, Davis-Silberman N, et al. (2004). "Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity.". Biochem. Biophys. Res. Commun. 324 (1): 372-81. doi:10.1016/j.bbrc.2004.09.074. PMID 15465029.
Weiss S, Gottfried I, Mayrose I, et al. (2003). "The DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activity.". Mol. Cell. Biol. 23 (22): 7957-64. PMID 14585957.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Leonard JH, Cook AL, Van Gele M, et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.". Int. J. Cancer 101 (2): 103-10. doi:10.1002/ijc.10554. PMID 12209986.
Vahava O, Morell R, Lynch ED, et al. (1998). "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.". Science 279 (5358): 1950-4. PMID 9506947.
Erkman L, McEvilly RJ, Luo L, et al. (1996). "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.". Nature 381 (6583): 603-6. doi:10.1038/381603a0. PMID 8637595.
Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.". J. Neurosci. 15 (7 Pt 1): 4762-85. PMID 7623109.