POU3F4

From Wikipedia, the free encyclopedia

POU domain, class 3, transcription factor 4

Identifiers

POU3F4; BRAIN-4; BRN4; DFN3; OTF9

External IDs

OMIM: 300039 MGI: 101894 HomoloGene: 260

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • sensory perception of sound • organ morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000307 (mRNA)
NP_000298 (protein)

NM_008901 (mRNA)
NP_032927 (protein)

Location

Chr X: 82.65 - 82.65 Mb

Chr X: 107.02 - 107.02 Mb

Pubmed search

[1]

[2]

POU domain, class 3, transcription factor 4, also known as POU3F4, is a human gene.^[1]

[edit] References

^ Entrez Gene: POU3F4 POU domain, class 3, transcription factor 4.

[edit] Further reading

Bitner-Glindzicz M, Turnpenny P, Höglund P, et al. (1995). "Further mutations in Brain 4 (POU3F4) clarify the phenotype in the X-linked deafness, DFN3.". Hum. Mol. Genet. 4 (8): 1467–9. PMID 7581392.
de Kok YJ, van der Maarel SM, Bitner-Glindzicz M, et al. (1995). "Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4.". Science 267 (5198): 685–8. PMID 7839145.
Douville PJ, Atanasoski S, Tobler A, et al. (1994). "The brain-specific POU-box gene Brn4 is a sex-linked transcription factor located on the human and mouse X chromosomes.". Mamm. Genome 5 (3): 180–2. PMID 7911044.
Malik KF, Jaffe H, Brady J, Young WS (1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.". Brain Res. Mol. Brain Res. 45 (1): 99–107. PMID 9105675.
de Kok YJ, Cremers CW, Ropers HH, Cremers FP (1997). "The molecular basis of X-linked deafness type 3 (DFN3) in two sporadic cases: identification of a somatic mosaicism for a POU3F4 missense mutation.". Hum. Mutat. 10 (3): 207–11. doi:10.1002/(SICI)1098-1004(1997)10:3<207::AID-HUMU5>3.0.CO;2-F. PMID 9298820.
Phippard D, Heydemann A, Lechner M, et al. (1998). "Changes in the subcellular localization of the Brn4 gene product precede mesenchymal remodeling of the otic capsule.". Hear. Res. 120 (1-2): 77–85. PMID 9667433.
Hagiwara H, Tamagawa Y, Kitamura K, Kodera K (1998). "A new mutation in the POU3F4 gene in a Japanese family with X-linked mixed deafness (DFN3).". Laryngoscope 108 (10): 1544–7. PMID 9778298.
Shimazaki T, Arsenijevic Y, Ryan AK, et al. (1999). "A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation.". EMBO J. 18 (2): 444–56. doi:10.1093/emboj/18.2.444. PMID 9889200.
Xia AP, Kikuchi T, Minowa O, et al. (2002). "Late-onset hearing loss in a mouse model of DFN3 non-syndromic deafness: morphologic and immunohistochemical analyses.". Hear. Res. 166 (1-2): 150–8. PMID 12062767.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.