POU2F3

From Wikipedia, the free encyclopedia

POU domain, class 2, transcription factor 3

PDB rendering based on 1pou.

Available structures: 1pou

Identifiers

Symbol(s)

POU2F3; Epoc-1; FLJ40063; MGC126698; OCT11; PLA-1; Skn-1a

External IDs

OMIM: 607394 MGI: 102565 HomoloGene: 7898

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • epidermis development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014352 (mRNA)
NP_055167 (protein)

NM_011139 (mRNA)
NP_035269 (protein)

Location

Chr 11: 119.62 - 119.7 Mb

Chr 9: 42.88 - 42.96 Mb

Pubmed search

[1]

[2]

POU domain, class 2, transcription factor 3, also known as POU2F3, is a human gene.^[1]

[edit] References

^ Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3.

[edit] Further reading

Goldsborough AS, Healy LE, Copeland NG, et al. (1993). "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11.". Nucleic Acids Res. 21 (1): 127–34. PMID 8441607.
Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor.". J. Biol. Chem. 274 (37): 26399–406. PMID 10473598.
Sugihara TM, Kudryavtseva EI, Kumar V, et al. (2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300.". J. Biol. Chem. 276 (35): 33036–44. doi:10.1074/jbc.M103000200. PMID 11429405.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation.". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. PMID 12624109.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Enomoto Y, Enomoto K, Kitamura T, Kanda T (2004). "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines.". Oncogene 23 (29): 5014–22. doi:10.1038/sj.onc.1207653. PMID 15077167.
Jiménez-Mateo O, Rodríguez-Torres A, Avila S, Castrillo JL (2006). "The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression.". Placenta 27 (4-5): 357–66. doi:10.1016/j.placenta.2005.03.011. PMID 16005513.
Zhang Z, Huettner PC, Nguyen L, et al. (2006). "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer.". Oncogene 25 (39): 5436–45. doi:10.1038/sj.onc.1209530. PMID 16607278.
Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.