From Wikipedia, the free encyclopedia
| Potassium channel RNA editing signal |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed; Moxon SJ |
| Seed alignment: |
PubMed |
| Avg length: |
113.7 nucleotides |
| Avg identity: |
65% |
|
The potassium channel RNA editing signal is an RNA element found in human Kv1.1 and its homologues which directs the efficient modification of an adenosine to inosine by an adenosine deaminase acting on RNA (ADAR). The ADAR modification causes an isoleucine/valine recoding event which lies in the ion-conducting pore of the potassium channel. It is thought that this editing event targets the process of fast inactivation and allows a more rapid recovery from inactivation at negative potentials.[1]
[edit] References
- ^ Bhalla, T; Rosenthal JJ, Holmgren M, Reenan R (2004). "Control of human potassium channel inactivation by editing of a small mRNA hairpin". Nat Struct Mol Biol 11: 950–956. doi:10.1038/nsmb825. PMID 15361858.
[edit] External links
