POSTN

From Wikipedia, the free encyclopedia

Periostin, osteoblast specific factor

Identifiers

POSTN; MGC119510; MGC119511; OSF-2; PDLPOSTN; PN; RP11-412K4.1; periostin

External IDs

OMIM: 608777 MGI: 1926321 HomoloGene: 4730

Gene ontology
Molecular Function:	• protein binding • heparin binding
Cellular Component:	• proteinaceous extracellular matrix
Biological Process:	• skeletal development • cell adhesion • tissue development • extracellular matrix organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006475 (mRNA)
NP_006466 (protein)

NM_015784 (mRNA)
NP_056599 (protein)

Location

Chr 13: 37.03 - 37.07 Mb

Chr 3: 54.45 - 54.48 Mb

Pubmed search

[1]

[2]

Periostin, osteoblast specific factor, also known as POSTN, is a human gene.^[1]

[edit] References

^ Entrez Gene: POSTN periostin, osteoblast specific factor.

[edit] Further reading

Takeshita S, Kikuno R, Tezuka K, Amann E (1993). "Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I.". Biochem. J. 294 ( Pt 1): 271-8. PMID 8363580.
Sasaki H, Dai M, Auclair D, et al. (2001). "Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas.". Cancer 92 (4): 843-8. PMID 11550156.
Gillan L, Matei D, Fishman DA, et al. (2002). "Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility.". Cancer Res. 62 (18): 5358-64. PMID 12235007.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Shao R, Bao S, Bai X, et al. (2004). "Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.". Mol. Cell. Biol. 24 (9): 3992-4003. PMID 15082792.
Bao S, Ouyang G, Bai X, et al. (2004). "Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.". Cancer Cell 5 (4): 329-39. PMID 15093540.
Kim CJ, Yoshioka N, Tambe Y, et al. (2005). "Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells.". Int. J. Cancer 117 (1): 51-8. doi:10.1002/ijc.21120. PMID 15880581.
Chang Y, Lee TC, Li JC, et al. (2005). "Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma.". Head Neck 27 (10): 873-82. doi:10.1002/hed.20253. PMID 16136586.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.
Yan W, Shao R (2006). "Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation.". J. Biol. Chem. 281 (28): 19700-8. doi:10.1074/jbc.M601856200. PMID 16702213.
Försti A, Jin Q, Altieri A, et al. (2007). "Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis.". Breast Cancer Res. Treat. 101 (1): 83-93. doi:10.1007/s10549-006-9265-1. PMID 16807673.
Grigoriadis A, Mackay A, Reis-Filho JS, et al. (2007). "Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.". Breast Cancer Res. 8 (5): R56. doi:10.1186/bcr1604. PMID 17014703.
Baril P, Gangeswaran R, Mahon PC, et al. (2007). "Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.". Oncogene 26 (14): 2082-94. doi:10.1038/sj.onc.1210009. PMID 17043657.
Siriwardena BS, Kudo Y, Ogawa I, et al. (2007). "Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer.". Br. J. Cancer 95 (10): 1396-403. doi:10.1038/sj.bjc.6603431. PMID 17060937.
Li JS, Sun GW, Wei XY, Tang WH (2007). "Expression of periostin and its clinicopathological relevance in gastric cancer.". World J. Gastroenterol. 13 (39): 5261-6. PMID 17876898.