Porcine circovirus
From Wikipedia, the free encyclopedia
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Porcine Circovirus (PCV) is a single stranded DNA virus (class II), that is non-enveloped with an un-segmented circular genome. The viral capsid is icosahedral and approximately 17nm in diameter. PCV is a member of the virus family Circoviridae.
PCV are the smallest viruses replicating autonomously in eukaryotic cells.[1] They replicate in the nucleus of infected cells, utilising the host polymerase for genome amplification.
There are 2 strains: Type 1 PCV and Type 2 PCV
Type 1 PCV (first identified in 1974) readily infects but is not known to cause disease in swine; it is the type 2 that has caused problems in recent years with the increasing occurrence of postweaning multisystemic wasting syndrome (PMWS) which over time results in significant depletion of lymphocytes; post mortem of diseased animals reveals enlarged lymph nodes and abnormal lung tissue.
It is still unclear whether type 2 PCV (first isolated in 1997) actually causes PMWS, as infection with the virus alone causes no clinical signs, it appears to work synergistically with parvovirus, perhaps with parvovirus activating a latent form of circovirus or weakening the immune system enough for PCV to take hold. PCV1 and PCV2 show a high degree of sequence homology and a similar genomic organisation; nevertheless, the basis of the distinct pathogenicity has not yet been unravelled.[1]
[edit] See also
[edit] References
- ^ a b Mankertz P (2008). "Molecular Biology of Porcine Circoviruses", Animal Viruses: Molecular Biology. Caister Academic Press. ISBN 978-1-904455-22-6.
