PON1

Paraoxonase 1

Identifiers

PON1; ESA; PON

External IDs

Gene ontology
Molecular Function:	• aryldialkylphosphatase activity • arylesterase activity • lipid transporter activity • hydrolase activity
Cellular Component:	• extracellular region
Biological Process:	• response to external stimulus • response to toxin

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000446 (mRNA)
NP_000437 (protein)

NM_011134 (mRNA)
NP_035264 (protein)

Location

Pubmed search

Paraoxonase 1, also known as PON1, is a human gene.

It is responsible for hydrolyising organophosphates and other pesticides and nerve gasses.

[edit] Further reading

Furlong CE, Costa LG, Hassett C, et al. (1993). "Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification.". Chem. Biol. Interact. 87 (1-3): 35–48. PMID 8393745.
Furlong CE, Cole TB, Jarvik GP, Costa LG (2002). "Pharmacogenomic considerations of the paraoxonase polymorphisms.". Pharmacogenomics 3 (3): 341–8. doi:10.1517/14622416.3.3.341. PMID 12052142.
Mackness B, Durrington PN, Mackness MI (2003). "The paraoxonase gene family and coronary heart disease.". Curr. Opin. Lipidol. 13 (4): 357–62. PMID 12151850.
Costa LG, Cole TB, Furlong CE (2003). "Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates.". J. Toxicol. Clin. Toxicol. 41 (1): 37–45. PMID 12645966.
Getz GS, Reardon CA (2005). "Paraoxonase, a cardioprotective enzyme: continuing issues.". Curr. Opin. Lipidol. 15 (3): 261–7. PMID 15166781.
Mackness M, Mackness B (2005). "Paraoxonase 1 and atherosclerosis: is the gene or the protein more important?". Free Radic. Biol. Med. 37 (9): 1317–23. doi:10.1016/j.freeradbiomed.2004.07.034. PMID 15454272.
Furlong CE, Cole TB, Jarvik GP, et al. (2005). "Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.". Neurotoxicology 26 (4): 651–9. doi:10.1016/j.neuro.2004.08.002. PMID 16112327.