POMP

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Proteasome maturation protein
Identifiers
Symbol(s) POMP; C13orf12; HSPC014; PNAS-110; UMP1
External IDs MGI: 1913787 HomoloGene: 41077
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51371 66537
Ensembl ENSG00000132963 ENSMUSG00000029649
Uniprot Q9Y244 Q9CQT5
Refseq NM_015932 (mRNA)
NP_057016 (protein)		 NM_025624 (mRNA)
NP_079900 (protein)
Location Chr 13: 28.13 - 28.15 Mb Chr 5: 148.17 - 148.19 Mb
Pubmed search [1] [2]

Proteasome maturation protein, also known as POMP, is a human gene.[1] It is a short-lived maturation factor required for 20S proteasome subunit biogenesis.


[edit] References

  1. ^ Entrez Gene: POMP proteasome maturation protein.

[edit] Further reading

  • Griffin TA, Slack JP, McCluskey TS, et al. (2000). "Identification of proteassemblin, a mammalian homologue of the yeast protein, Ump1p, that is required for normal proteasome assembly.". Mol. Cell Biol. Res. Commun. 3 (4): 212–7. doi:10.1006/mcbr.2000.0213. PMID 10891394. 
  • Witt E, Zantopf D, Schmidt M, et al. (2000). "Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes.". J. Mol. Biol. 301 (1): 1–9. doi:10.1006/jmbi.2000.3959. PMID 10926487. 
  • Burri L, Höckendorff J, Boehm U, et al. (2000). "Identification and characterization of a mammalian protein interacting with 20S proteasome precursors.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10348–53. doi:10.1073/pnas.190268597. PMID 10973495. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Tian S, Liu W, Wu Y, et al. (2002). "Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.". Am. J. Physiol. Renal Physiol. 283 (1): F142–9. doi:10.1152/ajprenal.00258.2001. PMID 12060596. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Jayarapu K, Griffin TA (2004). "Protein-protein interactions among human 20S proteasome subunits and proteassemblin.". Biochem. Biophys. Res. Commun. 314 (2): 523–8. PMID 14733938. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Heink S, Ludwig D, Kloetzel PM, Krüger E (2005). "IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.". Proc. Natl. Acad. Sci. U.S.A. 102 (26): 9241–6. doi:10.1073/pnas.0501711102. PMID 15944226. 
  • Hirano Y, Hendil KB, Yashiroda H, et al. (2005). "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.". Nature 437 (7063): 1381–5. doi:10.1038/nature04106. PMID 16251969. 
  • Hoefer MM, Boneberg EM, Grotegut S, et al. (2006). "Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation.". Int. J. Biol. Macromol. 38 (3-5): 259–67. doi:10.1016/j.ijbiomac.2006.03.015. PMID 16624403. 
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