Polysorbate 80
From Wikipedia, the free encyclopedia
| Polysorbate 80[1] | |
|---|---|
 |
|
| IUPAC name | Polyoxyethylene (20) sorbitan monooleate |
| Other names | Tween 80 |
| Identifiers | |
| CAS number | [9005-65-6] |
| RTECS number | WG2932500 |
| Properties | |
| Molecular formula | C64H124O26 |
| Molar mass | 1310 g/mol |
| Appearance | Amber colored viscous liquid |
| Density | 1.06-1.09 g/mL, oily liquid |
| Boiling point |
> 100°C |
| Solubility in water | Very soluble |
| Solubility in other solvents | soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene |
| Viscosity | 300-500 centistokes (@25°C) |
| Hazards | |
| Main hazards | Irritant |
| NFPA 704 |
 0
1
0
|
| Flash point | 113 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
|
Polysorbate 80 (commercially also known as Tween 80, a registered trademark of ICI Americas, Inc.)[2] is a nonionic surfactant and emulsifier derived from polyoxylated sorbitan and oleic acid, and is often used in foods. Polysorbate 80 is a viscous, water-soluble yellow liquid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups which are polymers of ethylene oxide. In the nomenclature of polysorbates, the numeral designation following polysorbate refers to the lipophilic group, in this case the oleic acid (see polysorbate for more detail).
Polysorbate 80 is often used in ice cream to prevent milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, to hold air in the mixture, and provide a firmer texture, holding its shape as the ice cream melts.
Contents |
[edit] Other names
- Polyoxyethylene (20) sorbitan monooleate
- (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)
- Tween 80
- POE (20) sorbitan monooleate
Polysorbate 80 is also used in some eye drops (i.e. ROHTO cool redness reliever/lubricant eye drops)
[edit] Data
The critical micelle concentration of polysorbate 80 is reported as 0.012 mM[3] and 0.006mM.[4]
[edit] Medical use
Polysorbate 80 is used as an emulsifier in the manufacture of medications for parenteral administration, most notably in the popular anti-arrhythmic amiodarone. [5]
[edit] See also
- Polysorbate 20: Used as a wetting agent in mouth drops.
- Polysorbate 40
- Polysorbate 60: Used as an emulsifier in powdered drink preparations such as hot cocoa mix.
- Polysorbate 65
[edit] References
- ^ Merck Index, 13th Edition, 7664.
- ^ US PTO TESS Registry Number 2885675
- ^ Danny K. Chou, Rajesh Krishnamurthy, Theodore W. Randolph, John F. Carpenter, Mark Cornell Manning (2005). "Effects of Tween 20(R) and Tween 80(R) on the stability of albutropin during agitation". Journal of pharmaceutical sciences 94: 1368–1381.
- ^ Marc Thorsteinsson, et al (2005). "5-Dodecanoylaminofluorescein as a probe for the determination of crticial micelle concentration of detergents using fluorescence anisotropy". Analytical Biochemistry 340: 220–225. doi:.
- ^ Gautier & Bellamy. Pharmaceutical amiodarone composition for parenteral delivery. Retrieved on 2008-04-06.
