Polypeptide antibiotics

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Polypeptide antibiotics are a class of antibiotics used for eye, ear or bladder infections in addition to aminoglycosides. They are toxic, and are therefore not suitable for systemic administration, but are administered topically on the skin.^[1] They are usually applied directly to the eye or inhaled into the lungs; rarely given by injection.

Adverse effects are kidney and nerve damage when given by injection.

Examples include bacitracin, colistin, polymyxin B.

Their mechanism of action is protein inhibition, but is largely unknown^[2]

[edit] See also

• Polypeptide

[edit] References