Polypeptide N-acetylgalactosaminyltransferase

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Please improve this article if you can. (December 2007)

In enzymology, a polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.41) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-galactosamine + polypeptide $\rightleftharpoons$ UDP + N-acetyl-D-galactosaminyl-polypeptide

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and polypeptide, whereas its two products are UDP and N-acetyl-D-galactosaminyl-polypeptide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase. Other names in common use include protein-UDP acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase, UDP-N-acetylgalactosamine:kappa-casein polypeptide, N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycoprotein, acetylgalactosaminyltransferase, glycoprotein acetylgalactosaminyltransferase, polypeptide-N-acetylgalactosamine transferase, UDP-acetylgalactosamine-glycoprotein, acetylgalactosaminyltransferase, UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetyl-alpha-D-galactosamine:polypeptide, N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine-glycoprotein, N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:polypeptide, N-acetylgalactosaminyltransferase, and UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1. It has 2 cofactors: manganese, and Calcium.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1XHB, 2D7I, 2D7R, 2FFU, and 2FFV.

[edit] References

IUBMB entry for 2.4.1.41
BRENDA references for 2.4.1.41 (Recommended.)
PubMed references for 2.4.1.41
PubMed Central references for 2.4.1.41
Google Scholar references for 2.4.1.41
Sugiura M, Kawasaki T, Yamashina I (1982). "Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66". J. Biol. Chem. 257: 9501–7. PMID 6809738.
Takeuchi M, Yoshikawa M, Sasaki R and Chiba H (1985). "Purification and characterization of UDP-N-acetylgalactosamine-kappa-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow". Agric. Biol. Chem. 49: 1059–1069.