Polyenoic fatty acid isomerase

From Wikipedia, the free encyclopedia

In enzymology, a polyenoic fatty acid isomerase (EC 5.3.3.13) is an enzyme that catalyzes the chemical reaction

(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate (5Z,7E,9E,14Z,17Z)-icosapentaenoate

Hence, this enzyme has one substrate, (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate, and one product, (5Z,7E,9E,14Z,17Z)-icosapentaenoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming). Other names in common use include PFI, eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate, cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase, (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase, (incorrect), (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase, and (trans-double-bond-forming).

[edit] References

• IUBMB entry for 5.3.3.13
• BRENDA references for 5.3.3.13 (Recommended.)
• PubMed references for 5.3.3.13
• PubMed Central references for 5.3.3.13
• Google Scholar references for 5.3.3.13
• Wise ML, Hamberg M, Gerwick WH (1994). "Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina". Biochemistry. 33: 15223–32. PMID 7803384. 
• Wise ML, Soderstrom K, Murray TF, Gerwick WH (1996). "Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid". Experientia. 52: 88–92. PMID 8575565. 
• Wise ML, Rossi J, Gerwick WH (1997). "Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina". Biochemistry. 36: 2985–92. PMID 9062129. 
• Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, Gerwick WH (2002). "Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA". Arch. Biochem. Biophys. 401: 11–20. PMID 12054482. 

[edit] External links

• IUBMB entry for 5.3.3.13

• KEGG entry for 5.3.3.13

• BRENDA entry for 5.3.3.13

• NiceZyme view of 5.3.3.13

• EC2PDB: PDB structures for 5.3.3.13

• PRIAM entry for 5.3.3.13

• PUMA2 entry for 5.3.3.13

• IntEnz: Integrated Enzyme entry for 5.3.3.13

• MetaCyc entry for 5.3.3.13

• Atomic-resolution structures of enzymes belonging to this class