Poly(3-hydroxybutyrate) depolymerase

From Wikipedia, the free encyclopedia

In enzymology, a poly(3-hydroxybutyrate) depolymerase (EC 3.1.1.75) is an enzyme that catalyzes the chemical reaction

poly[(R)-3-hydroxybutanoate]n + H₂O $\rightleftharpoons$ poly[(R)-3-hydroxybutanoate]n-x + poly[(R)-3-hydroxybutanoate]x; x $\rightleftharpoons$ 1-5

Thus, the two substrates of this enzyme are [[poly[(R)-3-hydroxybutanoate]n]] and H₂O, whereas its two products are [[poly[(R)-3-hydroxybutanoate]n-x]] and [[poly[(R)-3-hydroxybutanoate]x; x]].

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is poly[(R)-3-hydroxybutanoate] hydrolase. Other names in common use include PHB depolymerase, poly(3HB) depolymerase, poly[(R)-hydroxyalkanoic acid] depolymerase, poly(HA) depolymerase, poly(HASCL) depolymerase, and poly[(R)-3-hydroxybutyrate] hydrolase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2D80 and 2D81.

[edit] References

IUBMB entry for 3.1.1.75
BRENDA references for 3.1.1.75 (Recommended.)
PubMed references for 3.1.1.75
PubMed Central references for 3.1.1.75
Google Scholar references for 3.1.1.75
Jendrossek D (2001). "Microbial degradation of polyesters". Adv. Biochem. Eng. Biotechnol. 71: 293–325. PMID 11217416.
Prieto MA, Garcia JL, Martinez M, Luengo JM (1999). "Novel biodegradable aromatic plastics from a bacterial source Genetic and biochemical studies on a route of the phenylacetyl-coa catabolon". J. Biol. Chem. 274: 29228–41. PMID 10506180.