Polar-amino-acid-transporting ATPase

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In enzymology, a polar-amino-acid-transporting ATPase (EC 3.6.3.21) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + polar amino acidout $\rightleftharpoons$ ADP + phosphate + polar amino acidin

The 3 substrates of this enzyme are ATP, H₂O, and polar amino acid, whereas its 3 products are ADP, phosphate, and polar amino acid.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (polar-amino-acid-importing). This enzyme is also called histidine permease. This enzyme participates in abc transporters - general.

[edit] References

IUBMB entry for 3.6.3.21
BRENDA references for 3.6.3.21 (Recommended.)
PubMed references for 3.6.3.21
PubMed Central references for 3.6.3.21
Google Scholar references for 3.6.3.21
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146: 271–8. PMID 7569321.
Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40: 81–136. PMID 9889977.
Nikaido K, Liu PQ, Ames GF (1997). "Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity". J. Biol. Chem. 272: 27745–52. PMID 9346917.
Walshaw DL, Lowthorpe S, East A, Poole PS (1997). "Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity". FEBS. Lett. 414: 397–401. PMID 9315727.