POLRMT

From Wikipedia, the free encyclopedia

Polymerase (RNA) mitochondrial (DNA directed)

Identifiers

POLRMT; APOLMT; MTRPOL; h-mtRPOL

External IDs

OMIM: 601778 MGI: 1915843 HomoloGene: 37996

Gene ontology
Molecular Function:	• DNA binding • DNA-directed RNA polymerase activity • transferase activity
Cellular Component:	• mitochondrion
Biological Process:	• DNA replication, synthesis of RNA primer • transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005035 (mRNA)
NP_005026 (protein)

NM_172551 (mRNA)
NP_766139 (protein)

Location

Chr 19: 0.57 - 0.58 Mb

Chr 10: 79.14 - 79.15 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) mitochondrial (DNA directed), also known as POLRMT, is a human gene.^[1]

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes.^[1]

[edit] References

^ ^a ^b Entrez Gene: POLRMT polymerase (RNA) mitochondrial (DNA directed).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Tiranti V, Savoia A, Forti F, et al. (1997). "Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database.". Hum. Mol. Genet. 6 (4): 615–25. PMID 9097968.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.". Mol. Cell. Biol. 23 (16): 5816–24. PMID 12897151.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Graziewicz MA, Longley MJ, Bienstock RJ, et al. (2004). "Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia.". Nat. Struct. Mol. Biol. 11 (8): 770–6. doi:10.1038/nsmb805. PMID 15258572.
Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.". EMBO J. 23 (23): 4606–14. doi:10.1038/sj.emboj.7600465. PMID 15526033.
Kravchenko JE, Rogozin IB, Koonin EV, Chumakov PM (2005). "Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin.". Nature 436 (7051): 735–9. doi:10.1038/nature03848. PMID 16079853.
Wang Z, Cotney J, Shadel GS (2007). "Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.". J. Biol. Chem. 282 (17): 12610–8. doi:10.1074/jbc.M700461200. PMID 17337445.