POLR3K

From Wikipedia, the free encyclopedia

Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa

Identifiers

POLR3K; C11; C11-RNP3; My010; RPC10; RPC11; hRPC11

External IDs

OMIM: 606007 MGI: 1914255 HomoloGene: 5610

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • DNA-directed RNA polymerase activity • zinc ion binding • transferase activity • metal ion binding
Cellular Component:	• nucleus • DNA-directed RNA polymerase III complex
Biological Process:	• RNA elongation • regulation of transcription, DNA-dependent • transcription from RNA polymerase III promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016310 (mRNA)
NP_057394 (protein)

NM_025901 (mRNA)
NP_080177 (protein)

Location

Chr 16: 0.04 - 0.04 Mb

Chr 2: 181.79 - 181.8 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa, also known as POLR3K, is a human gene.^[1]

This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription.^[1]

[edit] References

^ ^a ^b Entrez Gene: POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa.

[edit] Further reading

Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
Flint J, Thomas K, Micklem G, et al. (1997). "The relationship between chromosome structure and function at a human telomeric region.". Nat. Genet. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID 9054936.
Chédin S, Riva M, Schultz P, et al. (1999). "The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination.". Genes Dev. 12 (24): 3857–71. PMID 9869639.
Spakovskiĭ GV, Lebedenko EN (1999). "[Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III]". Bioorg. Khim. 24 (11): 877–80. PMID 10079944.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.". Mol. Cell. Biol. 22 (22): 8044–55. PMID 12391170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.". Science 312 (5777): 1215–7. doi:10.1126/science.1126431. PMID 16728641.
Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.". Mol. Cell 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.