POLR3D

From Wikipedia, the free encyclopedia

Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa

Identifiers

POLR3D; BN51T; RPC4; RPC53; TSBN51

External IDs

OMIM: 187280 MGI: 1914315 HomoloGene: 1303

Gene ontology
Molecular Function:	• DNA binding • DNA-directed RNA polymerase activity • transferase activity
Cellular Component:	• nucleus • DNA-directed RNA polymerase III complex
Biological Process:	• regulation of progression through cell cycle • transcription • transcription from RNA polymerase III promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001722 (mRNA)
NP_001713 (protein)

NM_025945 (mRNA)
NP_080221 (protein)

Location

Chr 8: 22.16 - 22.16 Mb

Chr 14: 69.17 - 69.18 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa, also known as POLR3D, is a human gene.^[1]

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.^[1]

[edit] References

^ ^a ^b Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa.

[edit] Further reading

Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
Greco A, Ittmann M, Barletta C, et al. (1989). "Chromosomal localization of human genes required for G1 progression in mammalian cells.". Genomics 4 (3): 240–5. PMID 2714790.
Ittmann M, Greco A, Basilico C (1988). "Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.". Mol. Cell. Biol. 7 (10): 3386–93. PMID 3683386.
Jackson AJ, Ittmann M, Pugh BF (1995). "The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing.". Mol. Cell. Biol. 15 (1): 94–101. PMID 7799973.
Ittmann MM (1994). "Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III.". Cell Growth Differ. 5 (7): 783–8. PMID 7947392.
Chong SS, Hu P, Hernandez N (2001). "Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex.". J. Biol. Chem. 276 (23): 20727–34. doi:10.1074/jbc.M100088200. PMID 11279001.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.". Mol. Cell. Biol. 22 (22): 8044–55. PMID 12391170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.