POLR1A

From Wikipedia, the free encyclopedia

Polymerase (RNA) I polypeptide A, 194kDa

Identifiers

POLR1A; RPA1; DKFZP586M0122; FLJ21915; MGC87965; RPO1-4

External IDs

Gene ontology
Molecular Function:	• DNA binding • DNA-directed RNA polymerase activity • protein binding • zinc ion binding • transferase activity • metal ion binding
Cellular Component:	• nucleus • DNA-directed RNA polymerase I complex
Biological Process:	• transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015425 (mRNA)
NP_056240 (protein)

NM_009088 (mRNA)
NP_033114 (protein)

Location

Chr 2: 86.11 - 86.19 Mb

Chr 6: 71.84 - 71.91 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) I polypeptide A, 194kDa, also known as POLR1A, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLR1A polymerase (RNA) I polypeptide A, 194kDa.

[edit] Further reading

Seither P, Coy JF, Pouska A, Grummt I (1997). "Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I.". Mol. Gen. Genet. 255 (2): 180–6. PMID 9236775.
Zhu L, Perlaky L, Henning D, Valdez BC (1998). "Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family.". Biochem. Mol. Biol. Int. 42 (5): 927–35. PMID 9285060.
Chen HK, Pai CY, Huang JY, Yeh NH (2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization.". Mol. Cell. Biol. 19 (12): 8536–46. PMID 10567578.
Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMID 11250903.
Yuan X, Zhao J, Zentgraf H, et al. (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMID 12393749.
Dundr M, Hoffmann-Rohrer U, Hu Q, et al. (2002). "A kinetic framework for a mammalian RNA polymerase in vivo.". Science 298 (5598): 1623–6. doi:10.1126/science.1076164. PMID 12446911.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMID 15226435.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Percipalle P, Fomproix N, Cavellán E, et al.. "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMID 16514417.