POLQ

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), theta

Identifiers

POLQ; POLH; DKFZp781A0112; PRO0327

External IDs

OMIM: 604419 MGI: 2155399 HomoloGene: 32727

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • damaged DNA binding • DNA-directed DNA polymerase activity • ATP binding • ATP-dependent helicase activity • transferase activity
Cellular Component:	• nucleoplasm
Biological Process:	• DNA replication • DNA repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_199420 (mRNA)
NP_955452 (protein)

NM_029977 (mRNA)
NP_084253 (protein)

Location

Chr 3: 122.63 - 122.75 Mb

Chr 16: 36.93 - 37.01 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), theta, also known as POLQ, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLQ polymerase (DNA directed), theta.

[edit] Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Sharief FS, Vojta PJ, Ropp PA, Copeland WC (1999). "Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase.". Genomics 59 (1): 90–6. doi:10.1006/geno.1999.5843. PMID 10395804.
Maga G, Shevelev I, Ramadan K, et al. (2002). "DNA polymerase theta purified from human cells is a high-fidelity enzyme.". J. Mol. Biol. 319 (2): 359–69. doi:10.1016/S0022-2836(02)00325-X. PMID 12051913.
Seki M, Marini F, Wood RD (2003). "POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.". Nucleic Acids Res. 31 (21): 6117–26. PMID 14576298.
Kawamura K, Bahar R, Seimiya M, et al. (2004). "DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.". Int. J. Cancer 109 (1): 9–16. doi:10.1002/ijc.11666. PMID 14735462.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Seki M, Masutani C, Yang LW, et al. (2005). "High-efficiency bypass of DNA damage by human DNA polymerase Q.". EMBO J. 23 (22): 4484–94. doi:10.1038/sj.emboj.7600424. PMID 15496986.
Chiapperino D, Cai M, Sayer JM, et al. (2006). "Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.". J. Biol. Chem. 280 (48): 39684–92. doi:10.1074/jbc.M508008200. PMID 16188888.
Zan H, Shima N, Xu Z, et al. (2005). "The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.". EMBO J. 24 (21): 3757–69. doi:10.1038/sj.emboj.7600833. PMID 16222339.
Cruet-Hennequart S, Coyne S, Glynn MT, et al. (2006). "UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.". DNA Repair (Amst.) 5 (4): 491–504. doi:10.1016/j.dnarep.2006.01.008. PMID 16520097.
Chen YW, Cleaver JE, Hanaoka F, et al. (2006). "A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents.". Mol. Cancer Res. 4 (4): 257–65. doi:10.1158/1541-7786.MCR-05-0118. PMID 16603639.
Yuasa MS, Masutani C, Hirano A, et al. (2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.". Genes Cells 11 (7): 731–44. doi:10.1111/j.1365-2443.2006.00974.x. PMID 16824193.
Choi JY, Stover JS, Angel KC, et al. (2006). "Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site.". J. Biol. Chem. 281 (35): 25297–306. doi:10.1074/jbc.M605699200. PMID 16835218.
Kino K, Ito N, Sugasawa K, et al. (2007). "Translesion synthesis by human DNA polymerase eta across oxidative products of guanine.". Nucleic Acids Symp Ser (Oxf) (48): 171–2. doi:10.1093/nass/48.1.171. PMID 17150533.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.