POLM

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), mu

PDB rendering based on 2dun.

Available structures: 2dun, 2htf

Identifiers

Symbol(s)

POLM; Tdt-N

External IDs

OMIM: 606344 MGI: 1860191 HomoloGene: 41170

Gene ontology
Molecular Function:	• magnesium ion binding • DNA binding • DNA-directed DNA polymerase activity • DNA nucleotidylexotransferase activity • transferase activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• DNA replication • somatic hypermutation of immunoglobulin genes • B cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013284 (mRNA)
NP_037416 (protein)

NM_017401 (mRNA)
NP_059097 (protein)

Location

Chr 7: 44.08 - 44.09 Mb

Chr 11: 5.73 - 5.74 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), mu, also known as POLM, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLM polymerase (DNA directed), mu.

[edit] Further reading

Shimazaki N, Fujita K, Koiwai O (2002). "[Expression and function of terminal deoxynucleotidyl-transferase and discovery of novel DNA polymerase mu]". Seikagaku 74 (3): 227–32. PMID 11974916.
Domínguez O, Ruiz JF, Laín de Lera T, et al. (2000). "DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.". EMBO J. 19 (7): 1731–42. doi:10.1093/emboj/19.7.1731. PMID 10747040.
Aoufouchi S, Flatter E, Dahan A, et al. (2000). "Two novel human and mouse DNA polymerases of the polX family.". Nucleic Acids Res. 28 (18): 3684–93. PMID 10982892.
Haracska L, Johnson RE, Unk I, et al. (2002). "Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14256–61. doi:10.1073/pnas.261560798. PMID 11724965.
Duvauchelle JB, Blanco L, Fuchs RP, Cordonnier AM (2002). "Human DNA polymerase mu (Pol mu) exhibits an unusual replication slippage ability at AAF lesion.". Nucleic Acids Res. 30 (9): 2061–7. PMID 11972346.
Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA (2002). "Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.". Mol. Cell. Biol. 22 (14): 5194–202. PMID 12077346.
Zhang Y, Wu X, Guo D, et al. (2003). "Lesion bypass activities of human DNA polymerase mu.". J. Biol. Chem. 277 (46): 44582–7. doi:10.1074/jbc.M207297200. PMID 12228225.
Chiu A, Pan L, Li Z, et al. (2002). "DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.". Am. J. Pathol. 161 (4): 1349–55. PMID 12368208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nick McElhinny SA, Ramsden DA (2003). "Polymerase mu is a DNA-directed DNA/RNA polymerase.". Mol. Cell. Biol. 23 (7): 2309–15. PMID 12640116.
Covo S, Blanco L, Livneh Z (2004). "Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity.". J. Biol. Chem. 279 (2): 859–65. doi:10.1074/jbc.M310447200. PMID 14581466.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Washington MT, Minko IG, Johnson RE, et al. (2004). "Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa.". Mol. Cell. Biol. 24 (13): 5687–93. doi:10.1128/MCB.24.13.5687-5693.2004. PMID 15199127.
Roettger MP, Fiala KA, Sompalli S, et al. (2004). "Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu.". Biochemistry 43 (43): 13827–38. doi:10.1021/bi048782m. PMID 15504045.
Ruiz JF, Lucas D, García-Palomero E, et al. (2004). "Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate.". Nucleic Acids Res. 32 (19): 5861–73. doi:10.1093/nar/gkh929. PMID 15520469.
Nick McElhinny SA, Havener JM, Garcia-Diaz M, et al. (2005). "A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.". Mol. Cell 19 (3): 357–66. doi:10.1016/j.molcel.2005.06.012. PMID 16061182.
Juárez R, Ruiz JF, Nick McElhinny SA, et al. (2006). "A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis.". Nucleic Acids Res. 34 (16): 4572–82. doi:10.1093/nar/gkl457. PMID 16963491.